leptin resistance: a possible interface between obesity and pulmonary-related disorders
نویسندگان
چکیده
evidence acquisition elevated serum leptin levels are regarded as an established marker of obesity. it is also reported that obese asthmatic patients have maximum serum leptin levels compared to other groups such as non-obese asthmatics, and normal obese and non obese subjects without asthma. in addition to having an appetite suppressing effect, leptin also regulates certain acute-phase protein expressions including α-1 antitrypsin (a1at) in the liver. conclusions on the basis of prior studies, it could be hypothesized that, in obese asthmatic patients, the highest degree of leptin failure/resistance might lead to the creation of an imbalance between ne and its inhibitor a1at. to ascertain this, large scale prospective studies are warranted to assess the comparative serum leptin and a1at levels and ne activity in asthmatic non-obese and obese patients, simultaneously. such studies might help to devise novel interventional therapies for the treatment of pulmonary-related problems including asthma, chronic obstructive pulmonary disorder (copd), and other lung defects in susceptible obese subjects in the future. results a1at is a protease inhibitor that counterbalances the activity of the neutrophil elastase (ne) enzyme. a1at reductions in obese-leptin resistant subjects lead to increased ne activity. the overactivity of ne degrades lung tissue proteins, which may lead to pulmonary disorders including asthma. context under normal physiological conditions, leptin regulates body weight by creating a balance between food intake and energy expenditure. however, in obesity, serum leptin levels increase and become defective to retain energy balance.
منابع مشابه
Leptin Resistance: A Possible Interface Between Obesity and Pulmonary-Related Disorders
CONTEXT Under normal physiological conditions, leptin regulates body weight by creating a balance between food intake and energy expenditure. However, in obesity, serum leptin levels increase and become defective to retain energy balance. EVIDENCE ACQUISITION Elevated serum leptin levels are regarded as an established marker of obesity. It is also reported that obese asthmatic patients have m...
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1 MD, General Clinical Research Center and Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa. Correspondência para: Marcelo Correia, MSc, MD, PhD, Department of Clinical Medicine. State University of Rio de Janeiro. Av. Lineu de Paula Machado, 850 – 22470-040 – Rio de Janeiro, RJ. E-mail: [email protected] Recebido: 5/5/2008 Aceito: 28/5/20...
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عنوان ژورنال:
international journal of endocrinology and metabolismجلد ۱۴، شماره ۱، صفحات ۰-۰
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