screening of membrane active antimicrobial metabolites produced by soil actinomycetes using membrane models

Membrane-active metabolites produced by soil actinomycetes using chromatic phospholipid/polydiacetylene vesicles.

Increased resistance of pathogens toward existing antibiotics has compelled the research efforts to introduce new antimicrobial substances. Drugs with new and less resistant-prone targets to antimicrobial activity have a high priority for drug development activities. Cell membrane seems to be a potential target for new antibiotic agent development to overcome resistance. In this study, A total ...

X. Functions of collateral metabolites produced by some actinomycetes

Executive summary: Bacteria biosynthesize secondary metabolites (collaterals) or in other words a large class of biologically active bio compounds, which have applications in agriculture and the pharmaceutical industry. If knowledge’s about bacilli are more advanced (focused on practical applications has enzymes) in the case of actinomycetes the most information has been obtained from studies o...

Molecular Characterization of a Fungus Producing Membrane Active Metabolite and Analysis of the Produced Secondary Metabolite

Background: The majority of studies on soil Aspergillus concern the isolation and characterization of the antimicrobial compounds produced by this organism. Our previous studies indicated an isolated Aspergillus strain soil to be of interest, and this subject is further investigated here. Method:  Soil samples of various locations in Iran were collected. Extract from Aspergillus sp. culture was...

Nontoxic membrane-active antimicrobial arylamide oligomers.

Characterization of antimicrobial metabolites produced by halophilic Actinomyces isolated from Aran-Bidgol and Maharlu lakes

  Introduction: The purpose of this study was isolation of halophilic Actinomyces and the evaluation of their potential for producing antimicrobial metabolites. Material and method: To isolate antimicrobial metabolites producing Actinomyces, culture supernatant of 51 halophilic Actinnomyces isolates were assessed against Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, Staphylococcu...

Antimicrobial metabolites produced by an intertidal Acremonium furcatum.

In a screening for antimicrobial metabolites, amides of D-allo- and L-isoleucine derivatives were isolated from the culture of a marine strain of Acremonium furcatum. Structural elucidation of these compounds was performed by analysis of spectroscopic data and confirmed by synthesis. All of the compounds, natural and synthetic intermediates, were bioassayed against bacteria and phytopathogenic ...