antibacterial, antifungal and cytotoxic evaluation of some new quinazolinone derivatives
نویسندگان
چکیده
quinazolinone ring system is renown because of its wide spectrum of pharmacological activities due to various substitutions on this ring system. in this study, the minimum inhibitory concentration of the synthesized compounds in our laboratory was determined by micro dilution alamar blue ® assay against six strains of bacteria (three gram-positive and three gram-negative) and three strains of fungi. following a broth micro dilution minimum inhibitory concentration (mic) test, minimum bactericidal concentration (mbc) and minimum fungicidal concentration (mfc) tests were performed. cytotoxic effects of the compounds were measured using the mtt colorimetric assay on hela cell line. results of antimicrobial screening showed that compounds had better bacteriostatic activity against gram-negative bacteria. results from mbc revealed that these compounds had more significant bacteriostatic than bactericidal activities. nearly all screened compounds showed good activity against c. albicans and a. niger. results from mfc indicated that these compounds had better fungistatic rather than fungicidal activities. the synthesized target molecules were found to exhibit different cytotoxicity in the range of 10 to 100 µm on hela cell line. compounds 6 and 7 exhibited acceptable cytotoxicity approximately 50% at 10 µm concentration.
منابع مشابه
Antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3H)-quinazolinone derivatives
In this study antibacterial, antifungal and cytotoxic effects of some new 2,3-disubstituted 4(3H)-quinazolinone derivatives have been evaluated. The in vitro antibacterial and antifungal tests of new synthesized compounds were performed using MABA method against six strains of bacteria (three Grampositive and three Gram-negative) and three strains of fungi. Also Minimum Bactericidal Concentrati...
متن کاملsynthesis and antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives
متن کامل
antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives
in this study antibacterial, antifungal and cytotoxic effects of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives have been evaluated. the in vitro antibacterial and antifungal tests of new synthesized compounds were performed using maba method against six strains of bacteria (three gram-positive and three gram-negative) and three strains of fungi. also minimum bactericidal concentrat...
متن کاملSynthesis of Some New Quinazolinone Derivatives and Evaluation of Their Antimicrobial Activities
Wide range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives. Anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the benzoxazinone intermediate; subsequent addition of an amine provided the fused quinazolinones. Deoxyvasicinone which wa...
متن کاملSynthesis of Some New Quinazolinone Derivatives and Evaluation of Their Antimicrobial Activities
Wide range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives. Anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the benzoxazinone intermediate; subsequent addition of an amine provided the fused quinazolinones. Deoxyvasicinone which wa...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۲، صفحات ۸۷-۰
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