the cb1 receptor antagonist, am281, improves recognition loss induced by naloxone in morphine withdrawal mice
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the effect of nimodipine on memory loss following naloxone-induced morphine withdrawal in object recognition
we have previously evaluated the effect of nimodipine, l-type calcium channel blocker, on memory loss during spontaneous morphine withdrawal. in the present study the effect of nimodipine on memory loss in naloxone-induced morphine withdrawal mice was investigated. mice were made dependent by increasing doses of morphine for three days. object recognition task that was used for evaluation of me...
متن کاملThe effect of AM281, a cannabinoid antagonist, on memory performance during spontaneous morphine withdrawal in mice
Abrupt cessation of morphine leads to withdrawal signs and cognitive deficits. Endocannabinoid system is activated during withdrawal; therefore, the aim of the present study was to assess the effects of AM281, cannabinoid antagonist/inverse agonist, on memory deficit following spontaneous morphine withdrawal. Cognition was evaluated by using the object recognition task. The novel object recogni...
متن کاملSelective mGlu5 receptor antagonist MTEP attenuates naloxone-induced morphine withdrawal symptoms.
Several lines of evidence suggest a crucial involvement of glutamate in the mechanism of drug addiction. The involvement of group I mGlu receptors in the mechanism of addiction has also been proposed. Given the recent discovery of selective and brain penetrable mGlu5 receptor antagonists, the effects of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) were evaluated in the naloxone-precip...
متن کاملthe effects of spironolactone on morphine withdrawal induced memory loss by the object recognition task method in mice
previous reports showed that elevated levels of glucocorticoids following morphine withdrawal play an important role in memory impairment. in addition, glucocorticoid receptor (gr) inhibitors improved memory perfor-mance in morphine withdrawal mice. since mineralocorticoid receptor (mr) and grs complement each other, the aim of the current study was to evaluate the effects of spironolactone on ...
متن کاملthe effect of am281, a cannabinoid antagonist, on memory performance during spontaneous morphine withdrawal in mice
abrupt cessation of morphine leads to withdrawal signs and cognitive deficits. endocannabinoid system is activated during withdrawal; therefore, the aim of the present study was to assess the effects of am281, cannabinoid antagonist/inverse agonist, on memory deficit following spontaneous morphine withdrawal. cognition was evaluated by using the object recognition task. the novel object recogni...
متن کاملGeraniin attenuates naloxone-precipitated morphine withdrawal and morphine-induced tolerance in mice
BACKGROUND AND AIM Potentially life-threatening and unpleasant side effects associated with some analgesics have fueled the drive for the search for more analgesics with better side effect profiles. Geraniin, the most dominant secondary metabolite in the aqueous extract of the aerial parts of Phyllanthus muellerianus, has been shown to possess antinociceptive properties mediated partly by opioi...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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