cytotoxic effects of methamphetamine in rat hepatocytes

Metabolism and Cytotoxic Mechanisms of Nitroglycerin in Isolated Rat Hepatocytes

     It has been proposed that organic nitrates such as glyceryl trinitrate (GTN), used in the treatment of cardiovascular diseases, act by producing nitric oxide (NO). However, the biochemical pathway for NO formation from GTN is not well understood. In the present study, we showed that nitrate formation from GTN, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione w...

metabolism and cytotoxic mechanisms of nitroglycerin in isolated rat hepatocytes

it has been proposed that organic nitrates such as glyceryl trinitrate (gtn), used in the treatment of cardiovascular diseases, act by producing nitric oxide (no). however, the biochemical pathway for no formation from gtn is not well understood. in the present study, we showed that nitrate formation from gtn, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione was de...

Comparison of the Cytotoxic Effects of Nanosilver and Ancient Iranian and Pakistani Silver Kushtas on Primary Rat Hepatocytes and Human Cancer Cell Lines

Tumor growth is characterized by uncontrolled cell division. For centuries, silver kushta powder, composed of nano and submicro silver particles, has been used in traditional Iranian and Pakistani medicine for the treatment of melanoma and breast cancer. We have found that these nanocomposite particles are similar to silver nanoparticles (AgNps) in size and shape and that there are so differenc...

Effects of murine-derived anti-methamphetamine monoclonal antibodies on (+)-methamphetamine self-administration in the rat.

Two murine-derived anti-methamphetamine monoclonal antibodies were studied as potential pharmacokinetic antagonists of (+)-methamphetamine self-administration by rats. Intravenous administration of a 1 g/kg dose of the lower affinity [antibody equilibrium dissociation constant (K(d)) = 250 nM] monoclonal antibody (mAb) designated mAb6H8, 1 day before the start of several daily 2-h self-administ...

effects of scrophularia striata extracts on isolated rat hepatocytes

Effects of Rhynchophylline on Rat Cortical Neurons Stressed by Methamphetamine

Objective: To reveal the neurotoxicity of Methamphetamine (MA) on cortical neurons in rats and to study the protective effects of Rhynchophylline (Rhy) on MA treated neurons. Methods: The neurotoxicity of MA was measured with MTT assay in primary cultured cortical neurons. The viability of neurons treated MA for 48 h combined with Rhy or ketamine was also tested. Results: MTT assay showed that ...