lysosomal membrane leakiness and metabolic biomethylation play key roles in methyl tertiary butyl ether-induced toxicity and detoxification

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Toxicity of methyl tertiary-butyl ether on human blood lymphocytes.

Methyl tertiary-butyl ether (MTBE) is a synthetic solvent widely used as oxygenate in unleaded gasoline. Few studies have addressed the cellular toxicity of MTBE on some cell lines, and so far, no comprehensive study has been conducted to investigate the probable immunotoxicity of this compound. In this study, the toxicity of MTBE on human blood lymphocytes was evaluated. Blood lymphocytes were...

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The Acute and Subchronic Effects of Methyl Tertiary Butyl Ether on Some Fertility Indices in The Male Rats

Abstract Background and Objectives: Methyl-tertiary butyl ether (MTBE) is one of the fuel oxygenated additive that is used to reduce the environmental pollution resulting from engine combustion. This study was carried out to evaluate the acute (1 day) and subchronic (30 days) effects of MTBE on some fertility indices in the male rats. Methods: In this study, under two separate experiments (acut...

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Histologic and histomorphometric changes of testis following oral exposure to methyl tertiary-butyl ether in adult rat

Methyl tertiary-butyl ether (MTBE) is used to reduce carbon monoxide and ozone in urban air and to boost fuel octane. There is a lack of knowledge in the literature about the histomorphometric changes of the testis following exposure to MTBE. Therefore, this experimental study was performed to determine the effect of oral exposure to MTBE on histologic and histomorphometric changes of testis in...

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research in pharmaceutical sciences

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