evaluation of antinociceptive effect of pregabalin in mice and its combination with tramadol using tail-flick test
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Evaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test
The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...
متن کاملEvaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test
The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...
متن کاملEvaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test
The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...
متن کاملevaluation of antinociceptive effect of pregabalin in mice and its combination with tramadol using tail flick test
the development of combination therapy is a coherent approach in severe pain treatment. the present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. therefore, three groups of male mice received either pregabalin (1 to 400 mg/kg), tramadol (10 to 80 mg/kg) or their combination intraperitoneally. then latency time, maximum...
متن کاملEvaluation of the analgesic effect of Mellissa officinalis extract by tail-flick test in mice
Bibliographical studies have been done on plants that are used as analgesics in traditional medicine, and Mellissa officinalis or Lemon Balm (LB) that there are some evidence indicating for its application as analgesics or its probable analgesic effect was selected for evaluation of analgesic effect by tail-flick test in mice. After scientific identification, the leaves and flowered branches ...
متن کاملThe Role of NMDARs Ligands on Antinociceptive Effects of Pregabalin in the Tail Flick Test
BACKGROUND Pregabalin as a new anticonvulsant has been used in different pain treatments. OBJECTIVES The aim of this study was to investigate the role of N-methyl-D-aspartate (NMDA) ligands in antinociceptive effect of pregabalin in mice using tail flick. MATERIALS AND METHODS NMDA (15 and 30 mg/kg) as an agonist or MK801 (0.02 and 0.05 mg/kg) as an antagonist were injected intraperitoneall...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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