2-aryl quinolines related to some nsaids are selective cox-2 inhibitors

Cyclooxygenase (COX-2) selective inhibitors. Any better than NSAIDs?

Cutaneous hypersensitivity to multiple NSAIDs: never take tolerance to selective COX-2 inhibitors (COXIBs) for granted!

Nonsteroidal anti-inflammatory drugs are one of the most frequent causes of immediate drug-induced skin hypersensitivity reactions worldwide (1). While a proportion of patients show reactivity to single, specific drugs, many others are intolerant to multiple NSAIDs; about one half of multiple reactors suffer from chronic spontaneous urticaria, while in the remaining no underlying factor can be ...

COX - 2 Inhibitors , Other NSAIDs , and Cardiovascular Risk

The concept was appealing in its simplicity. Traditional nonsteroidal antiinflammatory drugs (NSAIDs) inhibited both isoforms of the enzyme cyclooxygenase responsible for the first step in the conversion of arachidonic acid into a variety of prostaglandins, thromboxanes, and leukotrienes throughout the body. The anti-inflammatory and pain-relieving effects of NSAIDs resulted from inhibition of ...

The double-edged sword of COX-2 selective NSAIDs.

The launch of the cyclooxygenase-2 (COX-2) selective NSAIDs was based on 2 hypotheses: (1) the major adverse effects limiting the usefulness of nonselective NSAIDs are gastrointestinal in nature and (2) COX-2 selective NSAIDs are associated with fewer gastrointestinal adverse effects than nonselective NSAIDs. At the time of the launch, neither of these hypotheses had been proven and, as documen...

Selective COX-2 inhibitors, NSAIDs and cardiovascular events – is celecoxib the safest choice?

Inhibitors of cyclo-oxogenase (COX) are widely used anti-inflammatory drugs. In recent years concerns have arisen about the cardiovascular safety of these drugs, initially because of reported associations between therapy with the COX-2 selective inhibitor rofecoxib and myocardial infarction. However, subsequent data have suggested an association between therapy with non-selective COX inhibitors...

Study of gastrointestinal toxicity of selective COX-2 inhibitors in comparison with conventional NSAIDs

Non-steroidal antiinflammatory drugs presently are the most widely used drugs in medicine and their annual sales in the world are more than 6 billion dollars. Presently, more than 100 NSAIDs have been tested clinically and more than 50 are there in the world market. Nearly 35 million people are taking them on daily basis and FDA has ranked them the most frequent cause of adverse drug reactions....