the synthesis and vasorelaxing activity of 1, 4-disubstituted 1,2,3-triazoles in rat thoracic aorta
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چکیده
منابع مشابه
comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولSynthesis and Biological Activity of Certain Mannich Bases Derivatives from 1, 2, 4-Triazoles
Substituted 1, 2, 4- Triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. These triazoles were used for preparation of different derivatives by two different schemes. In the first scheme the Mannich bases were prepared from 5- marcapto-s triazole Quinazolines. The 5-Marcato-s-Tr...
متن کاملsynthesis and antihypertensive activity of novel 4-[1-(4-x-benzyl)-5-imidazolyl] dihydropyridines in rat
a series of 1,4-dihydropyridine calcium channel blockers bearing 1-(4-x -benzyl)-5-imidazolyl substituent at 4 position (5a-e) (x=h, f) were synthesized and tested for antihypertensive activity in desoxycorticosterone acetate (doca)-induced hypertension in rats. amlodipine was used as the standard dihydropyridine. all compounds tested showed lower antihypertensive activity than that of amlodipi...
متن کاملsynthesis and biological activity of certain mannich bases derivatives from 1, 2, 4-triazoles
substituted 1, 2, 4- triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. these triazoles were used for preparation of different derivatives by two different schemes. in the first scheme the mannich bases were prepared from 5- marcapto-s triazole quinazolines. the 5-marcato-s-tr...
متن کاملSynthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
ABSTRACT By cycloaddition reaction of sodium azide with chalcone in the presence of CuO as a catalyst in DMF a 1,2,3-triazole are prepared in reaction with pentafluoropyridine to give 2-(tetrafluoropyridin-4-yl)-1,2,3-triazole derivatives in good yields and high regioselectivity. The regioselectivity of the compounds are confirmed by 19F-NMR and other spectroscopy. GRAPHICAL ABSTRACT
متن کاملHighly Efficient, One Pot, Solvent and Catalyst, Free Synthesis of Novel Quinazoline Derivatives under Ultrasonic Irradiation and Their Vasorelaxant Activity Isolated Thoracic Aorta of Rat
New quinazoline derivatives were prepared by one pot reaction of anthranilic acid, acetic anhydride and primary amines, under ultrasonic irradiation. As a result, Ultrasonic irradiation has led to affordable, clean synthesis of a variety of target compounds in much higher yields, than traditional methods. This method has numerous advantages: such as higher yields, shorter reactions time, and ea...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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