co-administration of metformin and n-acetylcysteine with dietary control improves the biochemical and histological manifestations in rats with non-alcoholic fatty liver

نویسندگان

naglaa mohamed el-lakkany

sayed hassan seif el-din

abdel-nasser abdel-aal sabra

olfat ali hammam

چکیده

non-alcoholic fatty liver disease (nafld) is a burgeoning health problem that affects 1/3 of the adult population and an increasing number of children in developed countries. oxidative stress and insulin resistance are the mechanisms that seem to be mostly involved in its pathogenesis. this study was conceived in a nafld rat model to evaluate the efficacy of both metformin (mtf) and n-acetylcysteine (nac) with dietary control on biochemical and histologic liver manifestations. rats were classified into nine groups; normal (i), nafld-induced by feeding high-fat diet (hfd; ii) for 12 weeks, nafld switched to regular diet (rd; iii), nafld-hfd or -rd treated with mtf in a dose of 150 mg/kg (iv, v), nac in a dose of 500 mg/kg (vi, vii) or mtf+nac (viii, ix) respectively for 8 weeks. after 20 weeks, the rats in group ii showed notable steatosis, lobular inflammation, fibrosis accompanied with elevated ( p < 0.05) serum alanine transaminase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), gamma glutamyl transferase (g-gt), cholesterol, triglycerides, ldl, vldl, leptin, tumor necrosis factor (tnf-α), transforming growth factor (tgf-β1) and hepatic malondialdehyde (mda) compared with group i. meanwhile, hepatic superoxide dismutase (sod), glutathione gsh with serum hdl, adiponectin were significantly decreased ( p < 0.05). these changes were to a less extent in group iii. mtf or nac individually resulted in improvement of most of these biochemical and histological parameters. these improvements were more pronounced in the combined groups viii and ix versus each drug alone. nac supplementation concomitant with mtf could be beneficial for the treatment of nafld and prevention of nonalcoholic steatohepatitis (nash).

Sign up for free to access the full text

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Co-administration of metformin and N-acetylcysteine with dietary control improves the biochemical and histological manifestations in rats with non-alcoholic fatty liver

Non-alcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects 1/3 of the adult population and an increasing number of children in developed countries. Oxidative stress and insulin resistance are the mechanisms that seem to be mostly involved in its pathogenesis. This study was conceived in a NAFLD rat model to evaluate the efficacy of both metformin (MTF) and N-acetylcys...

متن کامل

N-Acetylcysteine Improves Liver Function in Patients with Non-Alcoholic Fatty Liver Disease

BACKGROUND AND AIMS Non-alcoholic fatty liver change is a common disease of the liver in which oxidative stress plays a basic role. Studies are largely focused on protecting the liver by means of anti-oxidative material. The aim of this study is to evaluate the role of N- acetylcysteine in the process of liver injury. METHODS Thirty patients with non-alcoholic fatty liver steatosis were rando...

متن کامل

Clinical Manifestations and Diagnosis of Non-Alcoholic Fatty Liver Disease

Background & Objective: Nonalcoholic fatty liver diseases (NAFLD) is the major cause of hepatocellular carcinoma and increases the risk of mortality. Understanding the trends of its clinical and biochemical changes is essential to identify patients with NAFLD that are at the greatest risk of nonalcoholic steatohepatitis (NASH) and cirrhosis in Iran. M...

متن کامل

Association of Dietary Phytochemical Index and Anthropometric Risk Factors with Non-alcoholic Fatty Liver Disease in People with Diabetes

Background and Objectives: High prevalence of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus results in deleterious complications and morbidities. Therefore, the aim of this study was to assess nutritional and anthropometrical risk factors in progression of non-alcoholic fatty liver disease in diabetic patients.  Materials & Methods: Totally, 133 non-alcoholic fatty...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
research in pharmaceutical sciences

جلد ۱۱، شماره ۵، صفحات ۳۷۴-۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023