methyltetrahydrofolate reductase c677t mutation and 4g/5g plasminogen activator inhibitor-1 polymorphism in a child with deep vein thrombosis

Methyltetrahydrofolate Reductase C677T Mutation and 4G/5G Plasminogen Activator Inhibitor-1 Polymorphism in a Child with Deep Vein Thrombosis

Methyltetrahydrofolate Reductase C677T Mutation and 4G/5G Plasminogen Activator Inhibitor-1 Polymorphism in a Child with Deep Vein Thrombosis

Introduction Methyltetrahydrofolate reductase (MTHFR) enzyme is responsible for conversion of 5, 10methyl tetrahydrofolate to 5-tetrahydrofolate for folic acid (folate) synthesis. One of the most common MTHFR mutations is a nucleotide transition from C-to-T at position 677 that results in amino acid alteration from alanine to valine. Coinheritance of MTHFR mutation with Plasminogen activator in...

Association of Methylenetetrahydrofolate Reductase C677T Polymorphism with Hyperhomocysteinemia and Deep Vein Thrombosis in the Iranian Population

PURPOSE Deep venous thrombosis (DVT) is a common but elusive condition characterized by a high morbidity and mortality rate. The aim of the present study was to investigate the correlation between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with plasma total homocysteine (tHcy) levels and DVT risk in an Iranian population. MATERIALS AND METHODS Our study population consiste...

Hyperhomocysteinemia and of Methylenetetrahydrofolate Reductase (C677T) Genetic Polymorphism in Patients with Deep Vein Thrombosis

AIM To determine the concentration of total plasma homocysteine (tHcy) as well as different genotypes of methylenetetrahydrofolate reductase MTHFR (C677T) in healthy subjects and patients with deep vein thrombosis (DVT). MATERIAL AND METHODS The investigation comprised a total of 160 subjects divided in two main groups: 80 healthy subjects (control group) and 80 patients with deep vein thromb...

Methylenetetrahydrofolate reductase C677T mutation and risk of retinal vein thrombosis

BACKGROUND Elevated plasma homocysteine (Hcy) level has been established as a significant risk factor for venous thrombosis and cardiovascular disease. Homozygosity for the methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated with elevated plasma Hcy concentration and may contribute to retinal vein thrombosis (RVT) development. The aim of the present study was to inves...

Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty

BACKGROUND The onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality. The objective of this study was to investigate potential risk factors for DVT in patients after THA. METHODS Eligible patients with hip joint diseases who were scheduled for unilateral primary THA at our hospital were prospecti...