pediatric meduloblastoma and the prognostic value of mib-1 proliferative factor
نویسندگان
چکیده
background: medulloblastoma is the most common malignant brain tumor in children. the important factors in predicting survival are the extent of disease, proliferation index of the tumor cells, histopathologic class and the age at diagnosis. the percentage of ki-67 positive cells reflects the proliferation of the cells and is one of the critical factors which determine the growth of the tumor. monoclonal mib-1 antibody can be targeted against recombinant ki-67 and then demonstrated by immunohistochemical methods. materials and methods: formalin-fixed, paraffin-embedded tissue of 18 pediatric patients with medulloblastoma at mofid
منابع مشابه
Pediatric Meduloblastoma and the Prognostic Value of MIB-1 Proliferative Factor
Background: Medulloblastoma is the most common malignant brain tumor in children. The important factors in predicting survival are the extent of disease, proliferation index of the tumor cells, histopathologic class and the age at diagnosis. The percentage of Ki-67 positive cells reflects the proliferation of the cells and is one of the critical factors which determine the growth of the tumor....
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متن کاملMedulloblastoma: evaluation of proliferative index by monoclonal antibody Mib-1, its prognostic correlation and therapeutic implications.
In the past few years, the monoclonal antibody MIB-1 has been used by researchers in order to retrospectively study paraffin imbibed tumor fragments. The medulloblastoma is the most common malignant central nervous system tumor in childhood. The objectives were: determination of the mean Mib-1 LI value from these patients, as well as the prognostic value of the method. This retrospective study ...
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عنوان ژورنال:
iranian journal of blood and cancerجلد ۲، شماره ۱، صفحات ۷-۱۰
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