the association between polymorphisms in insulin and obesity related genes and risk of colorectal cancer

نویسندگان

mostafa rezaei tavirani proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran

akram safaei gastroentrology and liver diseases research center, shahid beheshti university of medical sciences, tehran, iran

mohammad reza zali gastroentrology and liver diseases research center, shahid beheshti university of medical sciences, tehran, iran

چکیده

colon cancer is cancer of the large intestine (colon), the lower part of digestive system and the third most common cancer in men and the second most common cancer in women worldwide. genetic background is thought to play a role in modulating individual risk to this cancer. many studies support an association for insulin pathway gene polymorphisms and   the regulation of tumor cell biology in colorectal cancer. in this review we discuss about polymorphisms in cancer -relationship genes which involve in insulin and obesity pathway and their association with colorectal cancer.

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عنوان ژورنال:
iranian journal of cancer prevention

جلد ۶، شماره ۴، صفحات ۰-۰

کلمات کلیدی
[ ' i n s u l i n ' , ' o b e s i t y ' , ' c o l o r e c t a l c a n c e r p l e a s e c i t e t h i s a r t i c l e a s ' , ' r e z a e i ' , ' t a v i r a n i m ' , ' s a f a e i a ' , ' z a l i m r . t h e a s s o c i a t i o n b e t w e e n p o l y m o r p h i s m s i n i n s u l i n a n d o b e s i t y r e l a t e d g e n e s a n d r i s k o f c o l o r e c t a l c a n c e r . i r a n j c a n c e r p r e v . 2 0 1 3 ' , ' 6 ( 4 ) ' , 1 7 9 , ' 8 5 . r e f e r e n c e s ' , ' 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 r u i l ' , ' f i s h e r t l ' , ' t h o m a s j ' , ' w h i t e m f . r e g u l a t i o n o f i n s u l i n / i n s u l i n ' , ' l i k e g r o w t h f a c t o r ' , ' 1 s i g n a l i n g b y p r o t e a s o m e ' , ' m e d i a t e d d e g r a d a t i o n o f i n s u l i n r e c e p t o r s u b s t r a t e ' , ' 2 . j o u r n a l o f b i o l o g i c a l c h e m i s t r y . 2 0 0 1 ' , ' 2 7 6 ( 4 3 ) ' , 4 0 3 6 2 , ' 7 . 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 p r o b s t ' , ' h e n s c h n m ' , ' w a n g h ' , ' g o h v h h ' , ' s e o w a ' , ' l e e h p ' , ' m i m i c y . d e t e r m i n a n t s o f c i r c u l a t i n g i n s u l i n ' , ' l i k e g r o w t h f a c t o r i a n d i n s u l i n ' , ' l i k e g r o w t h f a c t o r b i n d i n g p r o t e i n 3 c o n c e n t r a t i o n s i n a c o h o r t o f s i n g a p o r e m e n a n d w o m e n . c a n c e r e p i d e m i o l o g y b i o m a r k e r s & ' , ' p r e v e n t i o n . 2 0 0 3 ' , ' 1 2 ( 8 ) ' , 7 3 9 , ' 4 6 . 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s l a t t e r y m l ' , ' f i t z p a t r i c k f . c o n v e r g e n c e o f h o r m o n e s ' , ' i n f l a m m a t i o n ' , ' a n d e n e r g y ' , ' r e l a t e d f a c t o r s ' , ' a n o v e l p a t h w a y o f c a n c e r e t i o l o g y . c a n c e r p r e v e n t i o n r e s e a r c h . 2 0 0 9 ' , ' 2 ( 1 1 ) ' , 9 2 2 , ' 3 0 . 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l i s ' , ' l i u h ' , ' j i a y ' , ' d e n g y ' , ' z h a n g l ' , ' l u z ' , ' e t a l . a n o v e l s n p s d e t e c t i o n m e t h o d b a s e d o n g o l d m a g n e t i c n a n o p a r t i c l e s a r r a y a n d s i n g l e b a s e e x t e n s i o n . t h e r a n o s t i c s . 2 0 1 2 ' , ' 2 ( 1 0 ) ' , ' 9 6 7 . 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k i r s t e n f ' , ' k a r l ' , ' h e i n z g ' , ' a n g e l a r ' , ' a g n e s h w . g e n o m e ' , ' w i d e p r e d i c t i o n o f s p l i c e ' , ' m o d i f y i n g s n p s i n h u m a n g e n e s u s i n g a n e w a n a l y s i s p i p e l i n e c a l l e d a a s s i t e s . b m c b i o i n f o r m a t i c s . 1 2 . 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 b a r a s h c i . e t h i c a l i s s u e s i n p h a r m a c o g e n e t i c s . d r u g s . 2 0 0 1 . 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 h o y o c ' , ' m u r p h y s k ' , ' s c h i l d k r a u t j m ' , ' v i d a l a c ' , ' s k a a r d ' , ' m i l l i k a n r c ' , ' e t a l . i g f 2 r g e n e t i c v a r i a n t s ' , ' c i r c u l a t i n g i g f 2 c o n c e n t r a t i o n s a n d c o l o n c a n c e r r i s k i n a f r i c a n a m e r i c a n s a n d w h i t e s . d i s e a s e m a r k e r s . 2 0 1 2 ' , ' 3 2 ( 2 ) ' , 1 3 3 , ' 4 1 . 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 c o l a n g e l o l a ' , ' g a p s t u r s m ' , ' g a n n p h ' , ' d y e r a r ' , ' l i u k . c o l o r e c t a l c a n c e r m o r t a l i t y a n d f a c t o r s r e l a t e d t o t h e i n s u l i n r e s i s t a n c e s y n d r o m e . c a n c e r e p i d e m i o l o g y b i o m a r k e r s & ' , ' p r e v e n t i o n . 2 0 0 2 ' , ' 1 1 ( 4 ) ' , 3 8 5 , ' 9 1 . 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 r i s c h n . t h e g e n e t i c e p i d e m i o l o g y o f c a n c e r i n t e r p r e t i n g f a m i l y a n d t w i n s t u d i e s a n d t h e i r i m p l i c a t i o n s f o r m o l e c u l a r g e n e t i c a p p r o a c h e s . c a n c e r e p i d e m i o l o g y b i o m a r k e r s & ' , ' p r e v e n t i o n . 2 0 0 1 ' , ' 1 0 ( 7 ) ' , 7 3 3 , ' 4 1 . 1 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l i c h t e n s t e i n p ' , ' h o l m n v ' , ' v e r k a s a l o p k ' , ' i l i a d o u a ' , ' k a p r i o j ' , ' k o s k e n v u o m ' , ' e t a l . e n v i r o n m e n t a l a n d h e r i t a b l e f a c t o r s i n t h e c a u s a t i o n o f c a n c e r a n a l y s e s o f c o h o r t s o f t w i n s f r o m s w e d e n ' , ' d e n m a r k ' , ' a n d f i n l a n d . n e w e n g l a n d j o u r n a l o f m e d i c i n e . 2 0 0 0 ' , ' 3 4 3 ( 2 ) ' , 7 8 , ' 8 5 . 1 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l y n c h h t ' , ' d e l a c h a p e l l e a . h e r e d i t a r y c o l o r e c t a l c a n c e r . n e n g l j m e d . 2 0 0 3 ' , ' 3 4 8 ( 1 0 ) ' , 9 1 9 , ' 3 2 . 1 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 d e l a c h a p e l l e a . g e n e t i c p r e d i s p o s i t i o n t o c o l o r e c t a l c a n c e r . n a t u r e r e v i e w s c a n c e r . 2 0 0 4 ' , ' 4 ( 1 0 ) ' , 7 6 9 , ' 8 0 . 1 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 a a l t o n e n l a ' , ' p e l t o m ä k i p ' , ' l e a c h f s ' , ' s i s t o n e n p ' , ' p y l k k ä n e n l ' , ' m e c k l i n j p ' , ' e t a l . c l u e s t o t h e p a t h o g e n e s i s o f f a m i l i a l c o l o r e c t a l c a n c e r . s c i e n c e ( n e w y o r k ' , ' n y ) . 1 9 9 3 ' , ' 2 6 0 ( 5 1 0 9 ) ' , ' 8 1 2 . 1 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s p o r n m b ' , ' t o d a r o g j . a u t o c r i n e s e c r e t i o n a n d m a l i g n a n t t r a n s f o r m a t i o n o f c e l l s . n e w e n g l a n d j o u r n a l o f m e d i c i n e . 1 9 8 0 ' , ' 3 0 3 ( 1 5 ) ' , 8 7 8 , ' 8 0 . 1 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 y u h ' , ' r o h a n t . r o l e o f t h e i n s u l i n ' , ' l i k e g r o w t h f a c t o r f a m i l y i n c a n c e r d e v e l o p m e n t a n d p r o g r e s s i o n . j o u r n a l o f t h e n a t i o n a l c a n c e r i n s t i t u t e . 2 0 0 0 ' , ' 9 2 ( 1 8 ) ' , 1 4 7 2 , ' 8 9 . 1 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a j ' , ' p o l l a k m n ' , ' g i o v a n n u c c i e ' , ' c h a n j m ' , ' t a o y ' , ' h e n n e k e n s c h ' , ' e t a l . p r o s p e c t i v e s t u d y o f c o l o r e c t a l c a n c e r r i s k i n m e n a n d p l a s m a l e v e l s o f i n s u l i n ' , ' l i k e g r o w t h f a c t o r ( i g f ) ' , ' i a n d i g f ' , ' b i n d i n g p r o t e i n ' , ' 3 . j o u r n a l o f t h e n a t i o n a l c a n c e r i n s t i t u t e . 1 9 9 9 ' , ' 9 1 ( 7 ) ' , 6 2 0 , ' 5 . 1 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g i o v a n n u c c i e ' , ' p o l l a k m n ' , ' p l a t z e a ' , ' w i l l e t t w c ' , ' s t a m p f e r m j ' , ' m a j e e d n ' , ' e t a l . a p r o s p e c t i v e s t u d y o f p l a s m a i n s u l i n ' , ' l i k e g r o w t h f a c t o r ' , ' 1 a n d b i n d i n g p r o t e i n ' , ' 3 a n d r i s k o f c o l o r e c t a l n e o p l a s i a i n w o m e n . c a n c e r e p i d e m i o l o g y b i o m a r k e r s & ' , ' p r e v e n t i o n . 2 0 0 0 ' , ' 9 ( 4 ) ' , 3 4 5 , ' 9 . 1 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k a a k s r ' , ' t o n i o l o p ' , ' a k h m e d k h a n o v a ' , ' l u k a n o v a a ' , ' b i e s s y c ' , ' d e c h a u d h ' , ' e t a l . s e r u m c ' , ' p e p t i d e ' , ' i n s u l i n ' , ' l i k e g r o w t h f a c t o r ( i g f ) ' , ' i ' , ' i g f ' , ' b i n d i n g p r o t e i n s ' , ' a n d c o l o r e c t a l c a n c e r r i s k i n w o m e n . j o u r n a l o f t h e n a t i o n a l c a n c e r i n s t i t u t e . 2 0 0 0 ' , ' 9 2 ( 1 9 ) ' , 1 5 9 2 , ' 6 0 0 . 1 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 a r k a n i m ' , ' s a f a e i a ' , ' k a r i m i k ' , ' v a h e d i m ' , ' m o h e b i s r ' , ' f a t e m i s r ' , ' e t a l . a s s o c i a t i o n o f i g f ' , ' 1 g e n e ( r s 5 7 4 2 6 1 2 ) p o l y m o r p h i s m w i t h c o l o r e c t a l c a n c e r . j o u r n a l o f s a b z e v a r u n i v e r s i t y o f m e d i c a l s c i e n c e s . 2 0 1 2 ' , ' 1 9 ( 2 ) ' , 1 0 9 , ' 1 5 . 2 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 z e c e v i c m ' , ' a m o s c i ' , ' g u x ' , ' c a m p o s i m ' , ' j o n e s j s ' , ' l y n c h p m ' , ' e t a l . i g f 1 g e n e p o l y m o r p h i s m a n d r i s k f o r h e r e d i t a r y n o n p o l y p o s i s c o l o r e c t a l c a n c e r . j o u r n a l o f t h e n a t i o n a l c a n c e r i n s t i t u t e . 2 0 0 6 ' , ' 9 8 ( 2 ) ' , 1 3 9 , ' 4 3 . 2 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m o r i m o t o l m ' , ' n e w c o m b p a ' , ' w h i t e e ' , ' b i g l e r j ' , ' p o t t e r j d . i n s u l i n ' , ' l i k e g r o w t h f a c t o r p o l y m o r p h i s m s a n d c o l o r e c t a l c a n c e r r i s k . c a n c e r e p i d e m i o l o g y b i o m a r k e r s & ' , ' p r e v e n t i o n . 2 0 0 5 ' , ' 1 4 ( 5 ) ' , 1 2 0 4 , ' 1 1 . 2 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a k i r g . s m a l l i s b e a u t i f u l ' , ' i n s u l i n ' , ' l i k e g r o w t h f a c t o r s a n d t h e i r r o l e i n g r o w t h ' , ' d e v e l o p m e n t ' , ' a n d c a n c e r . j o u r n a l o f c l i n i c a l o n c o l o g y . 2 0 1 0 ' , ' 2 8 ( 3 3 ) ' , 4 9 8 5 , ' 9 5 . 2 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 j e n k i n s p ' , ' f r a j e s e v ' , ' j o n e s a ' , ' c a m a c h o ' , ' h u b n e r c ' , ' l o w e d ' , ' f a i r c l o u g h p ' , ' e t a l . i n s u l i n ' , ' l i k e g r o w t h f a c t o r i a n d t h e d e v e l o p m e n t o f c o l o r e c t a l n e o p l a s i a i n a c r o m e g a l y . j o u r n a l o f c l i n i c a l e n d o c r i n o l o g y & ' , ' m e t a b o l i s m . 2 0 0 0 ' , ' 8 5 ( 9 ) ' , 3 2 1 8 , ' 2 1 . 2 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 c l e m m o n s d r ' , ' m o s e s a c ' , ' m c k a y m j ' , ' s o m m e r a ' , ' r o s e n d m ' , ' r u c k l e j . t h e c o m b i n a t i o n o f i n s u l i n ' , ' l i k e g r o w t h f a c t o r i a n d i n s u l i n ' , ' l i k e g r o w t h f a c t o r ' , ' b i n d i n g p r o t e i n ' , ' 3 r e d u c e s i n s u l i n r e q u i r e m e n t s i n i n s u l i n ' , ' d e p e n d e n t t y p e 1 d i a b e t e s ' , ' e v i d e n c e f o r i n v i v o b i o l o g i c a l a c t i v i t y . j o u r n a l o f c l i n i c a l e n d o c r i n o l o g y & ' , ' m e t a b o l i s m . 2 0 0 0 ' , ' 8 5 ( 4 ) ' , 1 5 1 8 , ' 2 4 . 2 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l ö n n s ' , ' r o t h m a n n ' , ' s h a p i r o w r ' , ' f i n e h a ' , ' s e l k e r r g ' , ' b l a c k p m ' , ' e t a l . g e n e t i c v a r i a t i o n i n i n s u l i n ' , ' l i k e g r o w t h f a c t o r s a n d b r a i n t u m o r r i s k . n e u r o ' , ' o n c o l o g y . 2 0 0 8 ' , ' 1 0 ( 4 ) ' , 5 5 3 , ' 9 . 2 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 p o l l a k m n ' , ' s c h e r n h a m m e r e s ' , ' h a n k i n s o n s e . i n s u l i n ' , ' l i k e g r o w t h f a c t o r s a n d n e o p l a s i a . n a t u r e r e v i e w s c a n c e r . 2 0 0 4 ' , ' 4 ( 7 ) ' , 5 0 5 , ' 1 8 . 2 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g r i m b e r g a ' , ' c o h e n p . r o l e o f i n s u l i n l i k e g r o w t h f a c t o r s a n d t h e i r b i n d i n g p r o t e i n s i n g r o w t h c o n t r o l a n d c a r c i n o g e n e s i s . j o u r n a l o f c e l l u l a r p h y s i o l o g y . 2 0 0 0 ' , ' 1 8 3 ( 1 ) ' , 1 , ' 9 . 2 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 f ü r s t e n b e r g e r g ' , ' s e n n h j . i n s u l i n ' , ' l i k e g r o w t h f a c t o r s a n d c a n c e r . t h e l a n c e t o n c o l o g y . 2 0 0 2 ' , ' 3 ( 5 ) ' , 2 9 8 , ' 3 0 2 . 2 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s a n d h u m s ' , ' d u n g e r d b ' , ' g i o v a n n u c c i e l . i n s u l i n ' , ' i n s u l i n ' , ' l i k e g r o w t h f a c t o r ' , ' i ( i g f ' , ' i ) ' , ' i g f b i n d i n g p r o t e i n s ' , ' t h e i r b i o l o g i c i n t e r a c t i o n s ' , ' a n d c o l o r e c t a l c a n c e r . j o u r n a l o f t h e n a t i o n a l c a n c e r i n s t i t u t e . 2 0 0 2 ' , ' 9 4 ( 1 3 ) ' , 9 7 2 , ' 8 0 . 3 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g i o v a n n u c c i e . i n s u l i n ' , ' i n s u l i n ' , ' l i k e g r o w t h f a c t o r s a n d c o l o n c a n c e r ' , ' a r e v i e w o f t h e e v i d e n c e . t h e j o u r n a l o f n u t r i t i o n . 2 0 0 1 ' , ' 1 3 1 ( 1 1 ) ' , ' 3 1 0 9 s ' , ' 2 0 s . 3 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 p o l l a k m . i n s u l i n a n d i n s u l i n ' , ' l i k e g r o w t h f a c t o r s i g n a l l i n g i n n e o p l a s i a . n a t u r e r e v i e w s c a n c e r . 2 0 0 8 ' , ' 8 ( 1 2 ) ' , 9 1 5 , ' 2 8 . 3 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l e s t u n f f c ' , ' f a l l i n d ' , ' s c h o r k n j ' , ' b o u g n è r e s p . t h e i n s u l i n g e n e v n t r i s a s s o c i a t e d w i t h f a s t i n g i n s u l i n l e v e l s a n d d e v e l o p m e n t o f j u v e n i l e o b e s i t y . n a t u r e g e n e t i c s . 2 0 0 0 ' , ' 2 6 ( 4 ) ' , 4 4 4 , ' 6 . 3 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 o r t i z a p ' , ' t h o m p s o n c l ' , ' c h a k a ' , ' b e r g e r n a ' , ' l i l . i n s u l i n r e s i s t a n c e ' , ' c e n t r a l o b e s i t y ' , ' a n d r i s k o f c o l o r e c t a l a d e n o m a s . c a n c e r . 2 0 1 1 ' , ' 1 1 8 ( 7 ) ' , 1 7 7 4 , ' 8 1 . 3 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g u n t e r m j ' , ' h a y e s r b ' , ' c h a t t e r j e e n ' , ' y e a g e r m ' , ' w e l c h r ' , ' s c h o e n r e ' , ' e t a l . i n s u l i n r e s i s t a n c e ' , ' r e l a t e d g e n e s a n d a d v a n c e d l e f t ' , ' s i d e d c o l o r e c t a l a d e n o m a . c a n c e r e p i d e m i o l o g y b i o m a r k e r s & ' , ' p r e v e n t i o n . 2 0 0 7 ' , ' 1 6 ( 4 ) ' , 7 0 3 , ' 8 . 3 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k o o h e s t a n i n ' , ' t r a n t t ' , ' l e e w ' , ' w o l e v e r t m s ' , ' b r u c e w r . i n s u l i n r e s i s t a n c e a n d p r o m o t i o n o f a b e r r a n t c r y p t f o c i i n t h e c o l o n s o f r a t s o n a h i g h f a t d i e t . 1 9 9 7 . 3 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 o t a n i t ' , ' i w a s a k i m ' , ' s a s a z u k i s ' , ' i n o u e m ' , ' t s u g a n e s . p l a s m a c p e p t i d e ' , ' i n s u l i n l i k e g r o w t h f a c t o r i ' , ' i n s u l i n l i k e g r o w t h f a c t o r b i n d i n g p r o t e i n s a n d r i s k o f c o l o r e c t a l c a n c e r i n a n e s t e d c a s e c o n t r o l s t u d y ' , ' t h e j a p a n p u b l i c h e a l t h c e n t e r b a s e d p r o s p e c t i v e s t u d y . i n t e r n a t i o n a l j o u r n a l o f c a n c e r . 2 0 0 7 ' , ' 1 2 0 ( 9 ) . 3 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 b r u c e w r ' , ' g i a c c a a ' , ' m e d l i n e a . p o s s i b l e m e c h a n i s m s r e l a t i n g d i e t a n d r i s k o f c o l o n c a n c e r . c a n c e r e p i d e m i o l o g y b i o m a r k e r s & ' , ' p r e v e n t i o n . 2 0 0 0 ' , ' 9 ( 1 2 ) ' , 1 2 7 1 , ' 9 . 3 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s i n i c r o p e f a ' , ' f o s t e r n r ' , ' s a r g e n t d j ' , ' o & ' , ' # 0 3 9 ' , ' c o n n e l l m j ' , ' r a n k i n c . o b e s i t y i s a n i n d e p e n d e n t p r o g n o s t i c v a r i a b l e i n c o l o n c a n c e r s u r v i v o r s . c l i n i c a l c a n c e r r e s e a r c h . 2 0 1 0 ' , ' 1 6 ( 6 ) ' , 1 8 8 4 , ' 9 3 . 3 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k h a n d w a l a h m ' , ' m c c u t c h e o n i e ' , ' f l y v b j e r g a ' , ' f r i e n d k e . t h e e f f e c t s o f i n s u l i n ' , ' l i k e g r o w t h f a c t o r s o n t u m o r i g e n e s i s a n d n e o p l a s t i c g r o w t h . e n d o c r i n e r e v i e w s . 2 0 0 0 ' , ' 2 1 ( 3 ) ' , 2 1 5 , ' 4 4 . 4 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 w e i e k ' , ' m a j ' , ' p o l l a k m n ' , ' r i f a i n ' , ' f u c h s c s ' , ' h a n k i n s o n s e ' , ' e t a l . a p r o s p e c t i v e s t u d y o f c ' , ' p e p t i d e ' , ' i n s u l i n ' , ' l i k e g r o w t h f a c t o r ' , ' i ' , ' i n s u l i n ' , ' l i k e g r o w t h f a c t o r b i n d i n g p r o t e i n ' , 1 , ' a n d t h e r i s k o f c o l o r e c t a l c a n c e r i n w o m e n . c a n c e r e p i d e m i o l o g y b i o m a r k e r s & ' , ' p r e v e n t i o n . 2 0 0 5 ' , ' 1 4 ( 4 ) ' , 8 5 0 , ' 5 . 4 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l u k a n o v a a ' , ' z e l e n i u c h j a c q u o t t e a ' , ' l u n d i n e ' , ' m i c h e l i a ' , ' a r s l a n a a ' , ' r i n a l d i s ' , ' e t a l . p r e d i a g n o s t i c l e v e l s o f c p e p t i d e ' , ' i g f i ' , ' i g f b p 1 ' , ' 2 a n d 3 a n d r i s k o f e n d o m e t r i a l c a n c e r . i n t e r n a t i o n a l j o u r n a l o f c a n c e r . 2 0 0 4 ' , ' 1 0 8 ( 2 ) ' , 2 6 2 , ' 8 . 4 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 a r k a n i m ' , ' s a f a e i a ' , ' k a r i m i k ' , ' a r b a b i e ' , ' r o s t a m i f ' , ' i m a n m ' , ' e t a l . a s s o c i a t i o n o f t h e i n s u l i n g e n e p o l y m o r p h i s m a n d c o l o r e c t a l c a n c e r . k o o m e s h . 2 0 1 2 ' , ' 1 3 ( 2 ) ' , 1 7 2 , ' 6 . 4 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k i u n g a g a ' , ' r a j u j ' , ' s a b l j i c n ' , ' b a j a j g ' , ' g o o d c k ' , ' b i r d r p . e l e v a t e d i n s u l i n r e c e p t o r p r o t e i n e x p r e s s i o n i n e x p e r i m e n t a l l y i n d u c e d c o l o n i c t u m o r s . c a n c e r l e t t e r s . 2 0 0 4 ' , ' 2 1 1 ( 2 ) ' , 1 4 5 , ' 5 3 . 4 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m e i l l e u r k g ' , ' d o u m a t e y a ' , ' h u a n g h ' , ' c h a r l e s b ' , ' c h e n g ' , ' z h o u j ' , ' e t a l . c i r c u l a t i n g a d i p o n e c t i n i s a s s o c i a t e d w i t h o b e s i t y a n d s e r u m l i p i d s i n w e s t a f r i c a n s . j o u r n a l o f c l i n i c a l e n d o c r i n o l o g y & ' , ' m e t a b o l i s m . 2 0 1 0 ' , ' 9 5 ( 7 ) ' , 3 5 1 7 , ' 2 1 . 4 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 b l ü h e r m ' , ' b u l l e n j r j w ' , ' l e e j h ' , ' k r a l i s c h s ' , ' f a s s h a u e r m ' , ' k l ö t i n g n ' , ' e t a l . c i r c u l a t i n g a d i p o n e c t i n a n d e x p r e s s i o n o f a d i p o n e c t i n r e c e p t o r s i n h u m a n s k e l e t a l m u s c l e ' , ' a s s o c i a t i o n s w i t h m e t a b o l i c p a r a m e t e r s a n d i n s u l i n r e s i s t a n c e a n d r e g u l a t i o n b y p h y s i c a l t r a i n i n g . j o u r n a l o f c l i n i c a l e n d o c r i n o l o g y & ' , ' m e t a b o l i s m . 2 0 0 6 ' , ' 9 1 ( 6 ) ' , 2 3 1 0 , ' 6 . 4 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 y a m a j i t ' , ' i w a s a k i m ' , ' s a s a z u k i s ' , ' t s u g a n e s . i n t e r a c t i o n b e t w e e n a d i p o n e c t i n a n d l e p t i n i n f l u e n c e s t h e r i s k o f c o l o r e c t a l a d e n o m a . c a n c e r r e s e a r c h . 2 0 1 0 ' , ' 7 0 ( 1 3 ) ' , 5 4 3 0 , ' 7 . 4 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 g o n u l l u g ' , ' k a h r a m a n h ' , ' b e d i r a ' , ' b e k t a s a ' , ' y ü c e l i . a s s o c i a t i o n b e t w e e n a d i p o n e c t i n ' , ' r e s i s t i n ' , ' i n s u l i n r e s i s t a n c e ' , ' a n d c o l o r e c t a l t u m o r s . i n t e r n a t i o n a l j o u r n a l o f c o l o r e c t a l d i s e a s e . 2 0 1 0 ' , ' 2 5 ( 2 ) ' , 2 0 5 , ' 1 2 . 4 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 o t a k e s ' , ' t a k e d a h ' , ' f u j i s h i m a s ' , ' f u k u i t ' , ' o r i i t ' , ' s a t o t ' , ' e t a l . d e c r e a s e d l e v e l s o f p l a s m a a d i p o n e c t i n a s s o c i a t e d w i t h i n c r e a s e d r i s k o f c o l o r e c t a l c a n c e r . w o r l d j o u r n a l o f g a s t r o e n t e r o l o g y ' , ' w j g . 2 0 1 0 ' , ' 1 6 ( 1 0 ) ' , ' 1 2 5 2 . 4 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 b y e o n j s ' , ' j e o n g j y ' , ' k i m m j ' , ' l e e s m ' , ' n a m w h ' , ' m y u n g s j ' , ' e t a l . a d i p o n e c t i n a n d a d i p o n e c t i n r e c e p t o r i n r e l a t i o n t o c o l o r e c t a l c a n c e r p r o g r e s s i o n . i n t e r n a t i o n a l j o u r n a l o f c a n c e r . 2 0 1 0 ' , ' 1 2 7 ( 1 2 ) ' , 2 7 5 8 , ' 6 7 . 5 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m u t o h m ' , ' t e r a o k a n ' , ' t a k a s u s ' , ' t a k a h a s h i m ' , ' o n u m a k ' , ' y a m a m o t o m ' , ' e t a l . l o s s o f a d i p o n e c t i n p r o m o t e s i n t e s t i n a l c a r c i n o g e n e s i s i n & ' , ' l t ' , ' i & ' , ' g t ' , ' m i n & ' , ' l t ' , ' / i & ' , ' g t ' , ' a n d w i l d ' , ' t y p e m i c e . g a s t r o e n t e r o l o g y . 2 0 1 1 ' , ' 1 4 0 ( 7 ) ' , 2 0 0 0 , ' 8 . e 2 . 5 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m o o n h s ' , ' c h a m b e r l a n d j p ' , ' a r o n i s k ' , ' t s e l e n i ' , ' b a l a f o u t a s ' , ' m a n t z o r o s c s . d i r e c t r o l e o f a d i p o n e c t i n a n d a d i p o n e c t i n r e c e p t o r s i n e n d o m e t r i a l c a n c e r ' , ' i n v i t r o a n d e x v i v o s t u d i e s i n h u m a n s . m o l e c u l a r c a n c e r t h e r a p e u t i c s . 2 0 1 1 ' , ' 1 0 ( 1 2 ) ' , 2 2 3 4 , ' 4 3 . 5 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l i u l ' , ' z h o n g r ' , ' w e i s ' , ' y i n j y ' , ' x i a n g h ' , ' z o u l ' , ' e t a l . i n t e r a c t i o n s b e t w e e n g e n e t i c v a r i a n t s i n t h e a d i p o n e c t i n ' , ' a d i p o n e c t i n r e c e p t o r 1 a n d e n v i r o n m e n t a l f a c t o r s o n t h e r i s k o f c o l o r e c t a l c a n c e r . p l o s o n e . 2 0 1 1 ' , ' 6 ( 1 1 ) ' , ' e 2 7 3 0 1 . 5 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 y a m a u c h i t ' , ' k a m o n j ' , ' i t o y ' , ' t s u c h i d a a ' , ' y o k o m i z o t ' , ' k i t a s ' , ' e t a l . c l o n i n g o f a d i p o n e c t i n r e c e p t o r s t h a t m e d i a t e a n t i d i a b e t i c m e t a b o l i c e f f e c t s . n a t u r e . 2 0 0 3 ' , ' 4 2 3 ( 6 9 4 1 ) ' , 7 6 2 , ' 9 . 5 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 l u o z ' , ' s a h a a k ' , ' x i a n g x ' , ' r u d e r m a n n b . a m p k ' , ' t h e m e t a b o l i c s y n d r o m e a n d c a n c e r . t r e n d s i n p h a r m a c o l o g i c a l s c i e n c e s . 2 0 0 5 ' , ' 2 6 ( 2 ) ' , 6 9 , ' 7 6 . 5 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 w i l l i a m s c j ' , ' m i t s i a d e s n ' , ' s o z o p o u l o s e ' , ' h s i a ' , ' w o l k a ' , ' n i f l i a p ' , ' e t a l . a d i p o n e c t i n r e c e p t o r e x p r e s s i o n i s e l e v a t e d i n c o l o r e c t a l c a r c i n o m a s b u t n o t i n g a s t r o i n t e s t i n a l s t r o m a l t u m o r s . e n d o c r i n e ' , ' r e l a t e d c a n c e r . 2 0 0 8 ' , ' 1 5 ( 1 ) ' , 2 8 9 , ' 9 9 . 5 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a n t z o r o s c ' , ' p e t r i d o u e ' , ' d e s s y p r i s n ' , ' c h a v e l a s c ' , ' d a l a m a g a m ' , ' a l e x e d m ' , ' e t a l . a d i p o n e c t i n a n d b r e a s t c a n c e r r i s k . j o u r n a l o f c l i n i c a l e n d o c r i n o l o g y & ' , ' m e t a b o l i s m . 2 0 0 4 ' , ' 8 9 ( 3 ) ' , 1 1 0 2 , ' 7 . 5 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k a k l a m a n i v g ' , ' w i s i n s k i k b ' , ' s a d i m m ' , ' g u l d e n c ' , ' d o a ' , ' o f f i t k ' , ' e t a l . v a r i a n t s o f t h e a d i p o n e c t i n ( a d i p o q ) a n d a d i p o n e c t i n r e c e p t o r 1 ( a d i p o r 1 ) g e n e s a n d c o l o r e c t a l c a n c e r r i s k . j a m a ' , ' t h e j o u r n a l o f t h e a m e r i c a n m e d i c a l a s s o c i a t i o n . 2 0 0 8 ' , ' 3 0 0 ( 1 3 ) ' , 1 5 2 3 , ' 3 1 . 5 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 c a l l e e e ' , ' k a a k s r . o v e r w e i g h t ' , ' o b e s i t y a n d c a n c e r ' , ' e p i d e m i o l o g i c a l e v i d e n c e a n d p r o p o s e d m e c h a n i s m s . n a t u r e r e v i e w s c a n c e r . 2 0 0 4 ' , ' 4 ( 8 ) ' , 5 7 9 , ' 9 1 . 5 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 o u c h i n ' , ' k i h a r a s ' , ' a r i t a y ' , ' m a e d a k ' , ' k u r i y a m a h ' , ' o k a m o t o y ' , ' e t a l . n o v e l m o d u l a t o r f o r e n d o t h e l i a l a d h e s i o n m o l e c u l e s ' , ' a d i p o c y t e ' , ' d e r i v e d p l a s m a p r o t e i n a d i p o n e c t i n . c i r c u l a t i o n . 1 9 9 9 ' , ' 1 0 0 ( 2 5 ) ' , 2 4 7 3 , ' 6 . 6 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 r o s e d ' , ' k o m n i n o u d ' , ' s t e p h e n s o n g . o b e s i t y ' , ' a d i p o c y t o k i n e s ' , ' a n d i n s u l i n r e s i s t a n c e i n b r e a s t c a n c e r . o b e s i t y r e v i e w s . 2 0 0 4 ' , ' 5 ( 3 ) ' , 1 5 3 , ' 6 5 . 6 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k a r i m i k ' , ' a r k a n i m ' , ' s a f a e i a ' , ' v a h e d i m ' , ' m o h e b i s r s r f ' , ' v a f a e i m ' , ' e t a l . a s s o c i a t i o n o f a d i p o n e c t i n r e c e p t o r 1 r s 2 2 7 5 7 3 8 w i t h c o l o r e c t a l c a n c e r . s c i e n t i f i c j o u r n a l o f h a m a d a n u n i v e r s i t y o f m e d i c a l s c i e n c e s a n d h e a l t h s e r v i c e s . 2 0 1 2 . 6 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 a h i m a r s ' , ' f l i e r j s . a d i p o s e t i s s u e a s a n e n d o c r i n e o r g a n . t r e n d s i n e n d o c r i n o l o g y & ' , ' m e t a b o l i s m . 2 0 0 0 ' , ' 1 1 ( 8 ) ' , 3 2 7 , ' 3 2 . 6 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 a l e x e d m ' , ' p e t r i d o u e . l e p t i n a n d c a n c e r . l e p t i n . 2 0 0 7 ' , 2 0 1 , ' 2 3 . 6 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 t a m a k o s h i k ' , ' t o y o s h i m a h ' , ' w a k a i k ' , ' k o j i m a m ' , ' s u z u k i k ' , ' w a t a n a b e y ' , ' e t a l . l e p t i n i s a s s o c i a t e d w i t h a n i n c r e a s e d f e m a l e c o l o r e c t a l c a n c e r r i s k ' , ' a n e s t e d c a s e ' , ' c o n t r o l s t u d y i n j a p a n . o n c o l o g y . 2 0 0 5 ' , ' 6 8 ( 4 ' , ' 6 ) ' , 4 5 4 , ' 6 1 . 6 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s t a t t i n p ' , ' l u k a n o v a a ' , ' b i e s s y c ' , ' s ö d e r b e r g s ' , ' p a l m q v i s t r ' , ' k a a k s r ' , ' e t a l . o b e s i t y a n d c o l o n c a n c e r ' , ' d o e s l e p t i n p r o v i d e a l i n k ? i n t e r n a t i o n a l j o u r n a l o f c a n c e r . 2 0 0 4 ' , ' 1 0 9 ( 1 ) ' , 1 4 9 , ' 5 2 . 6 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k e r s h a w e e ' , ' f l i e r j s . a d i p o s e t i s s u e a s a n e n d o c r i n e o r g a n . j o u r n a l o f c l i n i c a l e n d o c r i n o l o g y & ' , ' m e t a b o l i s m . 2 0 0 4 ' , ' 8 9 ( 6 ) ' , 2 5 4 8 , ' 5 6 . 6 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 h a r d w i c k j c h ' , ' v a n d e n b r i n k g r ' , ' o f f e r h a u s g ' , ' v a n d e v e n t e r s j h ' , ' p e p p e l e n b o s c h m p . l e p t i n i s a g r o w t h f a c t o r f o r c o l o n i c e p i t h e l i a l c e l l s . g a s t r o e n t e r o l o g y . 2 0 0 1 ' , ' 1 2 1 ( 1 ) ' , 7 9 , ' 9 0 . 6 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 r o u e t ' , ' b e n z i n e b p ' , ' a p a r i c i o t ' , ' g u i l m e a u s ' , ' p o u z e t c ' , ' d e s c a t o i r e v ' , ' b u y s e m ' , ' e t a l . l e p t i n c o u n t e r a c t s s o d i u m b u t y r a t e ' , ' i n d u c e d a p o p t o s i s i n h u m a n c o l o n c a n c e r h t ' , ' 2 9 c e l l s v i a n f ' , ' κ b s i g n a l i n g . j o u r n a l o f b i o l o g i c a l c h e m i s t r y . 2 0 0 4 ' , ' 2 7 9 ( 1 6 ) ' , 1 6 4 9 5 , ' 5 0 2 . 6 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s l a t t e r y m l ' , ' p o t t e r j ' , ' c a a n b ' , ' e d w a r d s s ' , ' c o a t e s a ' , ' m a k n ' , ' e t a l . e n e r g y b a l a n c e a n d c o l o n c a n c e r b e y o n d p h y s i c a l a c t i v i t y . c a n c e r r e s e a r c h . 1 9 9 7 ' , ' 5 7 ( 1 ) ' , 7 5 , ' 8 0 . 7 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s l a t t e r y m ' , ' b a l l a r d ' , ' b a r b a s h r ' , ' e d w a r d s s ' , ' c a a n b j ' , ' p o t t e r j d . b o d y m a s s i n d e x a n d c o l o n c a n c e r ' , ' a n e v a l u a t i o n o f t h e m o d i f y i n g e f f e c t s o f e s t r o g e n ( u n i t e d s t a t e s ) . c a n c e r c a u s e s a n d c o n t r o l . 2 0 0 3 ' , ' 1 4 ( 1 ) ' , 7 5 , ' 8 4 . 7 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s l a t t e r y m l ' , ' c a a n b j ' , ' b e n s o n j ' , ' m u r t a u g h m . e n e r g y b a l a n c e a n d r e c t a l c a n c e r ' , ' a n e v a l u a t i o n o f e n e r g y i n t a k e ' , ' e n e r g y e x p e n d i t u r e ' , ' a n d b o d y m a s s i n d e x . n u t r i t i o n a n d c a n c e r . 2 0 0 3 ' , ' 4 6 ( 2 ) ' , 1 6 6 , ' 7 1 . 7 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a c a u l a y v . i n s u l i n ' , ' l i k e g r o w t h f a c t o r s a n d c a n c e r . b r i t i s h j o u r n a l o f c a n c e r . 1 9 9 2 ' , ' 6 5 ( 3 ) ' , ' 3 1 1 . 7 3 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 r e n e h a n a g ' , ' z w a h l e n m ' , ' m i n d e r c ' , ' o & ' , ' # 0 3 9 ' , ' d w y e r s t ' , ' s h a l e t s m ' , ' e g g e r m . i n s u l i n ' , ' l i k e g r o w t h f a c t o r ( i g f ) ' , ' i ' , ' i g f b i n d i n g p r o t e i n ' , 3 , ' a n d c a n c e r r i s k ' , ' s y s t e m a t i c r e v i e w a n d m e t a ' , ' r e g r e s s i o n a n a l y s i s . l a n c e t . 2 0 0 4 ' , ' 3 6 3 ( 9 4 1 8 ) ' , ' 1 3 4 6 . 7 4 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 f e r r y j r r j ' , ' c e r r i r w ' , ' c o h e n p . i n s u l i n ' , ' l i k e g r o w t h f a c t o r b i n d i n g p r o t e i n s ' , ' n e w p r o t e i n s ' , ' n e w f u n c t i o n s . h o r m o n e r e s e a r c h i n p a e d i a t r i c s . 1 9 9 9 ' , ' 5 1 ( 2 ) ' , 5 3 , ' 6 7 . 7 5 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 p i k e g ' , ' v o h . t h e g e n e t i c e n g i n e e r i n g o f h u m a n s . 7 6 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 f r a s c a f ' , ' p a n d i n i g ' , ' s c i a c c a l ' , ' p e z z i n o v ' , ' s q u a t r i t o s ' , ' b e l f i o r e a ' , ' e t a l . t h e r o l e o f i n s u l i n r e c e p t o r s a n d i g f ' , ' i r e c e p t o r s i n c a n c e r a n d o t h e r d i s e a s e s . a r c h i v e s o f p h y s i o l o g y a n d b i o c h e m i s t r y . 2 0 0 8 ' , ' 1 1 4 ( 1 ) ' , 2 3 , ' 3 7 . 7 7 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a t s u z a w a y . t h e m e t a b o l i c s y n d r o m e a n d a d i p o c y t o k i n e s . f e b s l e t t e r s . 2 0 0 6 ' , ' 5 8 0 ( 1 2 ) ' , ' 2 9 1 7 . 7 8 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 o k a m o t o y ' , ' k i h a r a s ' , ' f u n a h a s h i t ' , ' m a t s u z a w a y ' , ' l i b b y p . a d i p o n e c t i n ' , ' a k e y a d i p o c y t o k i n e i n m e t a b o l i c s y n d r o m e . c l i n i c a l s c i e n c e . 2 0 0 6 ' , 1 1 0 , 2 6 7 , ' 7 8 . 7 9 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 k a d o w a k i t ' , ' y a m a u c h i t . a d i p o n e c t i n a n d a d i p o n e c t i n r e c e p t o r s . e n d o c r i n e r e v i e w s . 2 0 0 5 ' , ' 2 6 ( 3 ) ' , 4 3 9 , ' 5 1 . 8 0 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 m a n t z o r o s c s . t h e r o l e o f l e p t i n i n h u m a n o b e s i t y a n d d i s e a s e ' , ' a r e v i e w o f c u r r e n t e v i d e n c e . a n n a l s o f i n t e r n a l m e d i c i n e . 1 9 9 9 ' , ' 1 3 0 ( 8 ) ' , ' 6 7 1 . 8 1 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 h a m i l t o n b s ' , ' p a g l i a d ' , ' k w a n a y ' , ' d e i t e l m . i n c r e a s e d o b e s e m r n a e x p r e s s i o n i n o m e n t a l f a t c e l l s f r o m m a s s i v e l y o b e s e h u m a n s . n a t u r e m e d i c i n e . 1 9 9 5 ' , ' 1 ( 9 ) ' , 9 5 3 , ' 6 . 8 2 . x a 0 x a 0 x a 0 x a 0 x a 0 x a 0 s h a r m a k ' , ' m c c u e p ' , ' d u n n s r . d i a b e t i c k i d n e y d i s e a s e i n t h e d b / d b m o u s e . a m e r i c a n j o u r n a l o f p h y s i o l o g y ' , ' r e n a l p h y s i o l o g y . 2 0 0 3 ' , ' 2 8 4 ( 6 ) ' , ' f 1 1 3 8 ' , ' f 4 4 . ' ]

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