emergence of new lineage of dengue virus 3 (genotype iii) in lucknow, india.

background and objectives: dengue has re-emerged as an important arboviral disease causing significant morbidity. it has become hyperendemic in the indian subcontinent with all four known dengue serotypes circulating. materials and methods: multiple sequence alignments and phylogenetic trees of denv-3 were constructed to determine the extent of the isolated dengue virus genetic heterogeneity and phylogeny. results: sequencing and phylogenetic analysis of the c-prm gene junction revealed an active circulation of a new lineage of denv-3 (genotype iii) in this region of india. conclusion: continuous epidemiological surveillance to monitor the incursion and spread of dengue virus genotypes in this region of india is needed.