leptin and atopic dermatitis in korean elementary school children
نویسندگان
چکیده
the prevalence of atopic dermatitis (ad) and obesity have been increasing considerably in korean school-children. ad is a chronic pruritic recurrent inflammatory skin disorder. leptin is secreted by adipocytes which has been suggested to be immunologically active; however, their role in ad has not yet been well understood. a total of 227 subjects out of 2,109 elementary school children were defined as having ad based on the isaac questionnaire survey. ninety subjects with ad, aged between 6 and 12 years, completed scoring of severity of ad (scorad), skin prick testing, blood tests for total ige, eosinophil counts, eosinophil cationic protein (ecp) and lipid profiles. serum leptin levels were also measured. a subject with atopic ad was defined as an ad patient showing at least 1 positive reaction to allergens in skin prick testing. there were no significant differences in age, body mass index, percentage of breast milk feeding, mode of delivery, prevalence of atopy, and lipid profiles between atopic ad and non-atopic ad subjects. the serum leptin levels (log mean±sd) were significantly higher in non-atopic ad group than in the atopic ad group (0.86±0.57 ng/ml vs 0.53±0.72 ng/ml, p=0.045). subjects with mild-to-moderate ad showed significantly higher serum leptin levels than those with severe ad (0.77±0.67 ng/ml vs 0.33±0.69 ng/ml, p=0.028). there was a marginal inverse correlation between the scorad index and the serum leptin concentration in total ad subjects (r=-0.216, p=0.053). the serum leptin levels were significantly higher in non-atopic ad subjects or mild-to-moderate ad subjects. leptin did not seem to be associated with ige-mediated inflammation in ad. obesity-associated high leptin differed between non-atopic ad and atopic ad subjects.
منابع مشابه
The prevalence of atopic dermatitis in Puerto Rican school children.
BACKGROUND Atopic dermatitis is a common inflammatory disease of the skin that usually begins in childhood and its diagnosis depends on clinical criteria. Recent reports have indicated that the worldwide prevalence of atopic dermatitis is increasing. The objective of this study was to determine the prevalence of atopic dermatitis in schoolchildren between the ages of six and seven in two school...
متن کاملAllergic rhinitis, atopic dermatitis, and asthma are associated with differences in school performance among Korean adolescents
Several studies have reported negative relations between allergic diseases and school performance but have not simultaneously considered various allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, and only examined a limited number of participants. The present study investigated the associations of allergic rhinitis, asthma, and atopic dermatitis with school performan...
متن کاملProbiotics and Atopic Dermatitis in Children
There is increasing interest in the potential beneficial role of probiotic supplementation in the prevention and treatment of atopic diseases in children. Probiotics are defined as ingested live microorganisms that, when administered in an adequate amount, confer a health benefit to the host. They are mainly represented by Lactobacilli and Bifidobacteria. Several epidemiological data demonstrat...
متن کاملAtopic Eczema (Atopic Dermatitis) in Children — Causes and Treatment
Atopic dermatitis is a common condition in children that is characterized by atopic eczematous skin rash that is highly pruritic. Children with atopic dermatitis might have other immunologic disorders, such as asthma and food allergies. The diagnosis of atopic eczema due to atopic dermatitis in children is a clinical-based one with little value of laboratory investigations. Once the diagnosis i...
متن کاملAtopic Eczema (Atopic Dermatitis) in Children — Causes and Treatment
Atopic dermatitis is a common condition in children that is characterized by atopic eczematous skin rash that is highly pruritic. Children with atopic dermatitis might have other immunologic disorders, such as asthma and food allergies. The diagnosis of atopic eczema due to atopic dermatitis in children is a clinical-based one with little value of laboratory investigations. Once the diagnosis i...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of allergy, asthma and immunologyجلد ۱۵، شماره ۲، صفحات ۱۳۸-۱۴۴
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023