amlodipine ameliorates up-regulation of et-1 in left ventricle of hypercholesterolemia rabbits
نویسندگان
چکیده
objective(s) in addition to antihypertensive effects, amlodipine may exhibit cardiovascular protective effects in heart tissue. the aim of this study was to evaluate the effects of amlodipine and/or high cholesterol diet on blood, heart tissue concentration and mrna expression of endothelin-1 (et-1) in male new zealand white rabbits. materials and methods a total of 40 male new zealand rabbits were divided into four groups: the normal control group, normal group receiving amlodipine, high-cholesterol diet group and high-cholesterol diet with amlodipine group. after 8 weeks, all the animals anesthetized and blood or tissues samples were collected. results after 8 weeks of a high cholesterol diet, the group with such a diet had a significantly higher ratio of left ventricle (lv) weight to body weight than the control group (p= 0.0001). after treatment with amlodipine for 8 weeks, et-1 level was reduced considerably in comparison with the control (p= 0.01) and high- cholesterol diet groupes (p= 0.01). amlodipine consumption caused significant reduction (p= 0.01) in the level of et-1 in heart tissues of high-cholesterol diet group but it had no remarkable effect on the reduction of heart tissue et-1 in amlodipine group compared with the control group. conclusion the present study demonstrates that ventricular prepro-et-1 mrna quantitatively increases in the high- cholesterol diet rabbits which results in development of ventricular hypertrophy. it seems that the treatment with amlodipine retards the progression of lv hypertrophy through attenuation of et-1 levels independent of lipid changes.
منابع مشابه
Amlodipine Ameliorates Up-Regulation of ET-1 in Left Ventricle of Hypercholesterolemia Rabbits
Objective(s) In addition to antihypertensive effects, amlodipine may exhibit cardiovascular protective effects in heart tissue. The aim of this study was to evaluate the effects of amlodipine and/or high cholesterol diet on blood, heart tissue concentration and mRNA expression of endothelin-1 (ET-1) in male New Zealand white rabbits. Materials and Methods A total of 40 male New Zealand rabbi...
متن کاملGestational diabetes influences the expression of hypertrophic genes in left ventricle of rat’s offspring
Objective(s): Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats.Materials and Methods: Diabetes was i...
متن کاملfaculty of psychology and social sciences group of anthropology master thesis in major of anthropology
چکیده پایان نامه (شامل خلاصه، اهداف، روش های اجرا و نتایج به دست آمده): کار جمع آوری گو یش های محلی در سال های اخیر شتاب امیدوار کننده ای به خود گرفته است. شاید از بارزترین اهداف جمع آوری گویش های مختلف، ثبت و ضبط آن، جلوگیری از نابودی و مهمتر از همه حل مشکلات دستوری زبان رسمی باشد. دقت در فرآیند های زبانی گویش های محلی نوع ارتباط مردم نواحی مختلف با پیرامون نشان را به ما نشان خواهد داد. از س...
Noninvasive Assessment of Myocardial Mechanics of the Left Ventricle in Rabbits Using Velocity Vector Imaging
BACKGROUND Our study aimed to investigate the feasibility of velocity vector imaging (VVI) to analyze left ventricular (LV) myocardial mechanics in rabbits at basal state. MATERIAL AND METHODS The animals used in this study were 30 New Zealand white rabbits. All rabbits underwent routine echocardiography under VVI-mode at basal state. The 2-dimensional (2-D) echocardiography images acquired i...
متن کاملideological and cultural orientations in translation of narrative text: the case of hajji baba of isfahan
در میان عواملی که ممکن است ذهن مترجم را هنگام ترجمه تحت تأثیر قرار دهند، می توان به مقوله انتقال ایدئولوژی از طریق متن یا گفتمان اشاره کرد. هدف از این تحقیق تجزیه و تحلیل جنبه های ایدئولوژیکی و فرهنگی متن مبدأ انگلیسی نوشته جیمز موریه تحت عنوان سرگذشت حاجی بابای اصفهانی ( 1823) و ترجمه فارسی میرزا حبیب اصفهانی(1880) بوده است.
comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۳، شماره ۴، صفحات ۲۳۲-۲۳۸
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023