hormonal and metabolic effects of polyunsaturated fatty acid (omega-3) on polycystic ovary syndrome induced rats under diet
نویسندگان
چکیده
objective(s): pcos (polycystic ovary syndrome) produces symptoms in approximately 5% to 10% of women of reproductive age (12–45 years old). it is thought to be one of the leading causes of female subfertility. this study aimed to confirm the role of nutrition containing omega-3 (polyunsaturated fatty acid) on control of experimental pco induced by estradiol-valerat in rats. materials and methods: wistar female rats (n=40) were allocated into control (n=10) and test groups (n= 30), test group was subdivided into 3 groups: g1, received omega-3 (240 mg/kg/orally/daily); g2 and g3 groups were induced pco by single injection of estradiol-valerate (16 mg/kg/im). group 3 received omega-3 (240 mg/kg/orally/daily) and low carbohydrate feeding for 60 subsequent days; on sixtieth day 5 ml blood samples and ovarian tissues of all rats in the group were removed and prepared for biochemical and hormonal analysis. results: catalase, gpx (glutathione peroxidase), sod (superoxide dismutase) in groups that received omega-3showed higher levels, but mda (malondialdehyde) level was significantly decreased (p<0.05) in comparison with other experimental groups. ovarian weights in both experimental and control groups were similar (p<0.05). level of serum fsh (follicle stimulating hormone) was decreased, but level of testosterone was significantly increased (p<0.05) in pco group in comparison with control and omega-3 groups. conclusion: results revealed that administration of omega-3 plus lower carbohydrate food significantly controlled pco syndrome and balanced fsh and testosterone.
منابع مشابه
Hormonal and metabolic effects of polyunsaturated fatty acid (omega-3) on polycystic ovary syndrome induced rats under diet
Objective(s): PCOS (polycystic ovary syndrome) produces symptoms in approximately 5% to 10% of women of reproductive age (12–45 years old). It is thought to be one of the leading causes of female subfertility. This study aimed to confirm the role of nutrition containing omega-3 (polyunsaturated fatty acid) on control of experimental PCO induced by estradiol-valerat in rats. Materials and Method...
متن کاملHormonal and metabolic effects of polyunsaturated fatty acid (omega-3) on polycystic ovary syndrome induced rats under diet
OBJECTIVE(S) PCOS (polycystic ovary syndrome) produces symptoms in approximately 5% to 10% of women of reproductive age (12-45 years old). It is thought to be one of the leading causes of female subfertility. This study aimed to confirm the role of nutrition containing omega-3 (polyunsaturated fatty acid) on control of experimental PCO induced by estradiol-valerat in rats. MATERIALS AND METHO...
متن کاملOmega-3 supplementation effects on polycystic ovary syndrome symptoms and metabolic syndrome
BACKGROUND Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder with unknown etiology and with different complications. The aim of this study was to evaluate the effect of omega-3 supplementation on PCOS symptoms and metabolic syndrome. MATERIALS AND METHODS This double-blind clinical trial was performed in 2015 in Alzahra and Shahid Beheshti Hospitals, Isfahan, Iran,...
متن کاملChanges in plasma metabolites and glucose homeostasis during omega-3 polyunsaturated fatty acid supplementation in women with polycystic ovary syndrome
BACKGROUND Both fish (FO) and flaxseed oils (FLX) are n-3 polyunsaturated fatty acids (PUFA). Fish oil contains long chain while FLX contains essential n-3 PUFA. We demonstrated that FO altered insulin secretion and resistance in polycystic ovary syndrome (PCOS) women but FLX did not. Surprisingly, the effects of FO were similar to those of the n-6 PUFA-rich soybean oil (SBO). Since increased b...
متن کاملEffectiveness of Omega-3 fatty acid for polycystic ovary syndrome: a systematic review and meta-analysis
OBJECTIVE To assess the effectiveness and safety of omega-3 fatty acid for patients with PCOS. METHODS In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of omega-3 fatty acid versus placebo or western medicine in women with PCOS. The study's registration number is CRD42017065859. The primary outcomes included the change of homeostatic model asse...
متن کاملDiet-induced metabolic syndrome model in rats
Background & Objective: Risk for heart disease, diabetes, and stroke increases with the number of the metabolic risk factors. In general, a person who has the metabolic syndrome is twice as likely to develop heart disease and five times as likely to develop diabetes as someone who does not have the metabolic syndrome. High-calorie-diet rodent models have contributed significantly to the analysi...
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عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۷، شماره ۲، صفحات ۱۲۳-۱۲۷
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