the effect of oral and intraurethral trimetazidine use on urethral healing

objective(s): we aimed to study the effect of trimetazidine (tmz) on urethral wound repair. materials and methods: a total of 52 male rats were used; 8 groups were formed: 1-week and 3-week control (c1,c3), sham (s1, s3), oral (ot1, ot3), and intraurethral tmz (iut1, iut3) groups. serum and urine total antioxidant capacity (tac), total oxidant capacity (toc), and 8-hydroxy-deoxy-guanosine (8-ohdg) were studied. hematoxyline-eosin was used for the histopathological study. in addition, tumor necrosis factor alpha (tnf- α), interleukin 1α, and β levels were compared across groups by an immunohistochemical method. results: there were significant differences between c3 and iut3, ot3 and iut3 with respect to serum tac in 3-week groups (p=0.013; p =0.001). serum toc levels were significantly different between c3 and iut3; s3 and ot3; and ot3 and iut3 groups (p =0.024; p =0.019; p =0.000, respectively). serum 8-ohdg levels were significantly different between c3 and ot3 groups (p=0.033). in the immunohistochemical examination, c1 and ot1; c1 and iut1; and s1, s3, ot1, ot3, iut1 groups were significantly different with respect to il-1β staining (p=0.007; p =0.000; p=0.009), while there was a significant difference between c3 and s3 with respect to il-1β (p =0.000). conclusion: tmz increased urinary total oxidant level; while increasing serum tac levels in the long-term. it also reduced serum tac levels in urethral use and caused an increase in serum toc levels with minimal effects on dna injury and repair. no effect was detected on il1 α and tnf, but partially reduced the effect on il-1 β levels.