genetic variation impacts in patients with major beta-thalassemia.
نویسندگان
چکیده
0
منابع مشابه
Genetic Variation Impacts in Patients with Major Beta-Thalassemia
Thalassemia is the most common single gene disorder around the world (1, 2). This disease is a type of chronic, microcytic and inherited anemia associated with defect in hemoglobin synthesis and reduction in life span of red blood cells (3). Thalassemia is distributed in Mediterranean, Middle East, Arabian Peninsula, Turkey, Iran, India, Burma and Southeast Asia (1). There are two types of thal...
متن کاملCytokine Gene Polymorphisms in Iranian Patients with Beta-Thalassemia Major
Background: β-thalassemia as a hereditary disease is defined as defective synthesis of β-globin chains, resulting in erythropoiesis abnormalities and severe anemia. Different studies have shown that cytokines and cytokine gene polymorphisms play a major role in the pathogenesis of β-thalassemia. Single nucleotide polymorphisms (SNPs) within the promoter region or other regulatory sequences ...
متن کاملEndocrine Disorders in Beta thalassemia Major Patients
Background Thalassemia is the most common hereditary disorder worldwide. The patient's’ survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity on various organs including endocrine glands. The study aimed to investigate endocrine disorders in patients with Beta-thalassemia major in the Southern Khorasan province, Iran. Materials and Methods In this des...
متن کاملPrevalence of HCVAb and HBsAg in Patients with Beta-thalassemia Major in Amirkola Thalassemia Center
Background and purpose: Beta-thalassemia major is a genetic disorder with known globin defect that leads to chronic hemolytic anemia. Due to the need for recurrent blood transfusion, the risk of infectious diseases such as hepatitis is higher in these patients. Materials and methods: This cross-sectional study recruited 518 patients with thalassemia major in Amirkola Thalassemia Center, 2013-2...
متن کاملHematuria in patients with Beta-thalassemia major.
INTRODUCTION Our information about renal involvement in beta-thalassemia major is limited. Recently, few studies have reported proteinuria, hypercalcuria, phosphaturia, and oversecretion of tubular damage markers; however, hematuria has not yet been meticulously studied in these patients. We investigated hematuria in patients with beta-thalassemia major. MATERIALS AND METHODS Urinalysis was p...
متن کاملQuality of Life and Some Related Factors in Patients With Beta Thalassemia Major in Southwest Iran
Background: Thalassemia is one of the most common genetic disorders in the world, especially in Iran. The study of various aspects affecting the physical and mental health of patients with beta thalassemia major has become more important. The aim of this study was to evaluate the Quality of life and some related factors in patients with beta-thalassemia major in Southwest Iran. Methods: In thi...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of public healthجلد ۴۴، شماره ۵، صفحات ۷۲۲-۳
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023