adiponectin and leptin molecular actions and clinical significance in breast cancer.
نویسندگان
چکیده
obesity is an important public health problem and major risk factor for postmenopausal breast cancer. adipose tissue is the major component involved in the control of the metabolism through energy homeostasis, adipocyte differentiation, insulin sensitivity and the activation of anti-inflammatory metabolic and immune pathways. leptin and adiponectin pathways are involved in proliferation process in breast cancer. current review describes potential relationship between the molecular actions and clinical significance of leptin and adiponectin in breast cancer.
منابع مشابه
Adiponectin and Leptin Molecular Actions and Clinical Significance in Breast Cancer
Obesity is an important public health problem and major risk factor for postmenopausal breast cancer. Adipose tissue is the major component involved in the control of the metabolism through energy homeostasis, adipocyte differentiation, insulin sensitivity and the activation of anti-inflammatory metabolic and immune pathways. Leptin and Adiponectin pathways are involved in proliferation process...
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The increasing percentage of obese individuals in the population and its independent association of increased risk for the development of cancer have heightened the necessity to understand the molecular mechanisms that underlie this connection. The deregulation of adipokines in the setting of obesity and their impact on cancer progression andmetastasis is one such area of research. Adipokines a...
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Obesity is a risk factor for breast cancer development. A recent hypothesis suggests that the adipokines, adiponectin and leptin, are involved in breast cancer development. This prompted us to investigate the role of adiponectin and leptin in mammary carcinogenesis. Adiponectin receptors (AdipoR1 and AdipoR2) and leptin receptor (Ob-Rt, representing all the isoforms of Ob-R) proteins were detec...
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The increasing percentage of obese individuals in the population and its independent association of increased risk for the development of cancer have heightened the necessity to understand the molecular mechanisms that underlie this connection. The deregulation of adipokines in the setting of obesity and their impact on cancer progression and metastasis is one such area of research. Adipokines ...
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عنوان ژورنال:
international journal of hematology-oncology and stem cell researchجلد ۸، شماره ۱، صفحات ۳۱-۴۰
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