conjugated estrogen in late-onset hemorrhagic cystitis associated with hematopoietic stem cell transplantation

نویسندگان

seyed asadollah mousavi hematology-oncology and sct research center, department of hematology-oncology, shariati hospital, tehran university of medical sciences, tehran, iran

vahid moazed hematology-oncology and sct research center, department of hematology-oncology, shariati hospital, tehran university of medical sciences, tehran, iran

niayesh mohebbi research center for rational use of drugs and department of clinical pharmacy, faculty of pharmacy, tehran university of medical sciences, tehran, iran

molouk hadjibabaie faculty of pharmacy, and research center for rational use of drugs, tehran university of medical sciences, tehran, iran

چکیده

abstract background hemorrhagic cystitis(hc)is one of the most challenging complications in hematopoietic stem cell transplantation(hsct). estrogen is one of the suggested treatments for controllingthis problem. material and methods we performed a randomizedcase - controlled study to evaluate the efficacy of oral conjugated estrogen on hc management in 56hsct patients.patients were randomly assigned to the drug group (received 6.25 mg conjugated estrogen oral tablets in a daily single dose during hematuria period) or control group. result the median time to complete response was 36 and 24 days in the drug and control group respectively. the median time of down stage was 24 days in the drug group and 12 daysin control group.adjusted for hc grades, the relative risk of complete response for patients in control group was 1.613 times more than that of patients in drug group; nevertheless, not significant (p=0.122). conclusion in conclusion,oral conjugated estrogen was not helpful in the management of hc.

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Conjugated Estrogen in Late-Onset Hemorrhagic Cystitis Associated with Hematopoietic Stem Cell Transplantation

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عنوان ژورنال:
international journal of hematology-oncology and stem cell research

جلد ۲۰۱۵، شماره ۱۰، صفحات ۰-۰

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