conjugated estrogen in late-onset hemorrhagic cystitis associated with hematopoietic stem cell transplantation
نویسندگان
چکیده
abstract background hemorrhagic cystitis(hc)is one of the most challenging complications in hematopoietic stem cell transplantation(hsct). estrogen is one of the suggested treatments for controllingthis problem. material and methods we performed a randomizedcase - controlled study to evaluate the efficacy of oral conjugated estrogen on hc management in 56hsct patients.patients were randomly assigned to the drug group (received 6.25 mg conjugated estrogen oral tablets in a daily single dose during hematuria period) or control group. result the median time to complete response was 36 and 24 days in the drug and control group respectively. the median time of down stage was 24 days in the drug group and 12 daysin control group.adjusted for hc grades, the relative risk of complete response for patients in control group was 1.613 times more than that of patients in drug group; nevertheless, not significant (p=0.122). conclusion in conclusion,oral conjugated estrogen was not helpful in the management of hc.
منابع مشابه
Conjugated Estrogen in Late-Onset Hemorrhagic Cystitis Associated with Hematopoietic Stem Cell Transplantation
Background: Hemorrhagic cystitis (HC) is one of the most challenging complications in hematopoietic stem cell transplantation (HSCT). Estrogen is one of the suggested treatments for controlling this problem. Subjects and Methods: We performed a randomized case-control study to evaluate the efficacy of oral conjugated estrogen on HC management in 56 HSCT patients. Patients were randomly assigned...
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عنوان ژورنال:
international journal of hematology-oncology and stem cell researchجلد ۲۰۱۵، شماره ۱۰، صفحات ۰-۰
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