hba<sub>1c</sub> in patients with polycystic ovary syndrome: a potential marker of inflammation

background: polycystic ovary syndrome (pcos) is a common endocrine disorder that is associated with increased inflammation, insulin resistance, and elevated risk of metabolic complications. hs-crp is the most reliable marker of inflammation in pcos patients. when hs-crp is elevated, it can indicate increased risk of cardiovascular disease. the purpose of the study was to determine if a certain value of hba1c in pcos patients should alert clinicians to increased inflammation (as defined by hs-crp >2 mg/l), thus potentially be indicative of increased risk of cardiovascular disease. methods: a cohort study was conducted on female patients between the ages of 20 to 45 years who fulfilled the national institute of health criteria for pcos. de-identified data of 46 patients with pcos were obtained. all clinical tests were conducted after a 12 hr overnight fast. hs-crp was measured by latex-enhanced immunonephelometry. logistic regression analysis was conducted to assess the association between hs-crp and hba1c. results: when various hba1c levels were considered, a cutoff of 5.3% correctly classified patients with hs-crp >2 mg/l at 80.4%. sensitivity was 83.3% and specificity was 75%. conclusion: an hba1c cut off of 5.3% may be appropriate to initiate efforts for early detection of increased inflammation as a potential sign of risk for cardiovascular disease.