frequency of y chromosome microdeletions among iranian infertile men with azoospermia and severe oligozoospermia: a meta-analysis
نویسندگان
چکیده
background: while multiple factors can contribute to male infertility, genetic factors, such as chromosomal disorders or y-chromosome microdeletion, are responsible for about 10% of male infertility. considering the role of y-chromosome microdeletions in men with oligozoospermia who volunteer for in vitro fertilization (ivf), the prevalence of such microdeletions in each particular community needs to be exactly determined. hence, the present study attempted to analyze the available literature on the frequency of chromosome microdeletion among iranian infertile men. methods: in the first stage, a systematic search was performed on international and iranian databases including pubmed, scopus, web of science, iranmedex, medlib, and scientific information database in order to extract all relevant studies published until december 1, 2014. results: according to the literature review and meta-analysis process, y chromosome microdeletions were present in about 12.1% (95% ci, 6.5-21.5) of iranian infertile men with azoospermia and severe oligozoospermia. conclusion: because of the presence of y-chromosome microdeletion in at least 12% of iranian infertile men, it is necessary all the ivf centers, implement this y-chromosome microdeletion screening tests in the work-up of male infertility.
منابع مشابه
Frequency of Y Chromosome Microdeletions Among Iranian Infertile Men with Azoospermia and Severe Oligozoospermia: A Meta-analysis
BACKGROUND While multiple factors can contribute to male infertility, genetic factors, such as chromosomal disorders or Y-chromosome microdeletion, are responsible for about 10% of male infertility. Considering the role of Y-chromosome micro-deletions in men with oligozoospermia who volunteer for in vitro fertilization (IVF), the prevalence of such microdeletions in each particular community ne...
متن کاملFrequency of Y chromosome microdeletions and chromosomal abnormalities in infertile Thai men with oligozoospermia and azoospermia.
AIM To investigate the possible causes of oligozoospermia and azoospermia in infertile Thai men, and to find the frequencies of Y chromosome microdeletions and cytogenetic abnormalities in this group. METHODS From June 2003 to November 2005, 50 azoospermic and 80 oligozoospermic men were enrolled in the study. A detailed history was taken for each man, followed by general and genital examinat...
متن کاملY Chromosome Microdeletions in Infertile Men with Non-obstructive Azoospermia and Severe Oligozoospermia
BACKGROUND The purpose of the study was to investigate the frequencies and types of Y chromosome microdeletions in infertile men and to analyze the relationship between the levels of reproductive hormones and Y microdeletions. METHODS A total of 1,226 infertile men were screened for Y chromosome microdeletions using multiplex PCR assay. Karyotype analysis was performed on peripheral blood lym...
متن کاملThe Prevalence of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia and Severe Oligospermia
OBJECTIVE Microdeletions of the Y chromosome long arm are the most common molecular genetic causes of severe infertility in men. They affect three regions including azoospermia factors (AZFa, AZFb and AZFc), which contain various genes involved in spermatogenesis. The aim of the present study was to reveal the patterns of Y chromosome microdeletions in Iranian infertile men referred to Royan In...
متن کاملthe prevalence of y chromosome microdeletions in iranian infertile men with azoospermia and severe oligospermia
objective: microdeletions of the y chromosome long arm are the most common molecular genetic causes of severe infertility in men. they affect three regions including azoospermia factors (azfa, azfb and azfc), which contain various genes involved in spermatogenesis. the aim of the present study was to reveal the patterns of y chromosome microdeletions in iranian infertile men referred to royan i...
متن کاملY-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia
The aim of the present work was to present the outcomes of the patients with Y-chromosome microdeletions treated by intracytoplasmic sperm injection (ICSI), either using fresh (TESE) or frozen-thawed (TESE-C) testicular sperm and ejaculated sperm (EJAC). The originality of this work resides in the comparisons between the different types of Y-microdeletions (AZFa, AZFb, and AZFc) and treatments,...
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عنوان ژورنال:
journal of reproduction and infertilityجلد ۱۷، شماره ۴، صفحات ۲۰۸-۲۱۳
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