ror2 promoter methylation change in osteoblastic differentiation of mesenchymal stem cells

ROR2 Promoter Methylation Change in Osteoblastic Differentiation of Mesenchymal Stem Cells

OBJECTIVE Osteoblasts arise from multipotent mesenchymal stem cells (MSCs) present in the bone marrow stroma and undergo further differentiation to osteocytes or bone cells. Many factors such as proteins present in the Wnt signaling pathway affect osteoblast differentiation. ROR2 is an orphan tyrosine kinase receptor that acts as a co-receptor in the non-canonical Wnt signaling pathway. However...

Evaluation of Changes in Global DNA Methylation during Osteoblastic Differentiation of Mesenchymal Stem Cells: A Laboratory Study

Background and Objectives: Control processes in osteoblastic differentiation of mesenchymal stem cells are not yet fully understood. Epigenetic mechanisms, especially the methylation of CpG Islands in the promoter of genes, are considered as one of the most important control mechanisms in stem cell differentiation. In the process of differentiation, it is debated whether only the methylation of...

different methylation patterns of runx2, osx, dlx5 and bsp in osteoblastic differentiation of mesenchymal stem cells

objective: runt-related transcription factor 2 (runx2) and osterix (osx) as two specific osteoblast transcription factors and distal-less homeobox 5 (dlx5) as a non-specific one are of paramount importance in regulating osteoblast related genes including osteocalcin, bone sialoprotein (bsp), osteopontin and collagen type iα1. the present study sets out to investigate whether epigenetic regulati...

does dna methylation plays a critical role in osteoblastic differentiation of mesenchymal stem cells (mscs)?

Different Methylation Patterns of RUNX2, OSX, DLX5 and BSP in Osteoblastic Differentiation of Mesenchymal Stem Cells

OBJECTIVE Runt-related transcription factor 2 (RUNX2) and osterix (OSX) as two specific osteoblast transcription factors and distal-less homeobox 5 (DLX5) as a non-specific one are of paramount importance in regulating osteoblast related genes including osteocalcin, bone sialoprotein (BSP), osteopontin and collagen type Iα1. The present study sets out to investigate whether epigenetic regulatio...

Does DNA Methylation Plays a Critical Role in Osteoblastic Differentiation of Mesenchymal Stem Cells (MSCs)?

1 Research Center of Thalassemia and Hemoglobinopathy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran 2 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran 3 Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands 4 Young Researchers Club, Science and Research Branch, Islamic Azad U...