synthesis of some nitrogen functional derivatives of 5-substituted-6-azauracil as biologically active compounds

Synthesis of Some Nitrogen Functional Derivatives of 5-substituted-6-azauracil as Biologically Active Compounds

3-Arylhydrazono-2,4-dioxo-4-phenylbutanoates have been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides. Reactions of the 3-arylhydrazono-2,4- dioxo-4-phenylbutanoates with 1-aminoguanidine, semicarbazide, and thiosemicarbazide gave 5-substituted 2-imino-6-azauracil (3a), 6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds ...

Synthesis of Nitrogen Functional Derivatives of 5-substituted-6-azauracil as one of the Four Nucleobases in the Nucleic Acid of RNA

3-Arylhydrazono-2,4-dioxo-4-phenylbutanoateshave been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides.Reactions ofthe 3-arylhydrazono-2,4-dioxo-4-phenylbutanoateswith 1-aminoguanidine, semicarbazide, and thiosemicarbazidegave5-substituted 2-imino-6-azauracil (3a),6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds - IR, 1H...

synthesis of nitrogen functional derivatives of 5-substituted-6-azauracil as one of the four nucleobases in the nucleic acid of rna

Synthesis of Some New Piperazine-iV^iV'-bis-substituted Derivatives As Potential Biologically Active Agents

In a search for new bactericidal and fungicidal agents some new piperazine-TV, TV'-bis-substituted derivatives have been prepared and characterized by their elemental analysis, IR, *H N M R , and mass spectral d a t a . T h e ant ibacter ia l and antifungal activities of all p repared c o m p o u n d s have been determined using Gentamycin as s t a n d a r d antibiotic. Some c o m p o u n d s s...

A Facile Synthesis and Characterization of Biologically Active Halogen Substituted 1-Acetyl 3, 5-Diphenylpyrazole Derivatives

Flavonoids comprise a large family of plant derived polyphenolic compounds classified as flavonols, chalcones, aurones, flavanones, isoflavones, flavans, flavanonols, flavanols, and flavones differencing from each other in their structural group arrangements [1]. α,β-Unsaturated ketones display a wide range of pharmacological properties, including cytotoxicity towards different cancer cell line...

Synthesis of some biologically active 2,4’-bipyridine-5-carbonitriles carrying the 4-Aminohenylthio moiety

A series of new 6-amino-4aryl-2’-[(4-Aminophenyl)thio]-2,4’-bipyridine-5-carbonitriles (3a-h) were synthesized from 4-aminothiophenol (1). The reaction of 4-aminothiophenol with 4-acetyl-2-chloropyridine yielded 1-{2-[(4-aminophenyl)thio]pyridin-4-yl}ethanone(2).Furthertreatment of  2 with aromatic aldehydes in the presence of alcoholic malanonitrile in ammonium acetate gave compounds (3a-h). T...