fasting reduces the binding between sugar and protein; new insights into diabetic complications
نویسندگان
چکیده
fasting has numerous biological, physical and mental health advantages or that as some physicians cure their patients by prescribing fasting to them. fasting protects people from many diseases such as cancer, cardiovascular diseases, and diabetes complications. the main health-promoting effects of fasting are increased production of neurotrophic factors, neuroendocrine activation, hormetic stress response, reduced mitochondrial oxidative stress, general decrease of signals associated with aging, and promotion of autophagy. this article briefly describes the molecular view of the effects of fasting on human health, according to our laboratory results, which are obtained by biophysical and biochemical methods. based on our results, the presence of 3-β-hydroxybutyrate (bhb) as a liver produced metabolite in the fasting condition protects the body against toxicity of human serum albumin and insulin glycation products. our results demonstrated that, bhb protects protein against sugar binding, inhibits the alteration of the protein structure and diminishes ages formation. by this way, bhb inhibits friend to foe transformation in proteins to protect us against diabetic complications.
منابع مشابه
Fasting Reduces the Binding between Sugar and Protein; New Insights into Diabetic Complications
Fasting has numerous biological, physical and mental health advantages or that as some physicians cure their patients by prescribing fasting to them. Fasting protects people from many diseases such as cancer, cardiovascular diseases, and diabetes complications. The main health-promoting effects of fasting are increased production of neurotrophic factors, neuroendocrine activation, hormetic stre...
متن کاملThe Relationship between Socket Blood Sugar and Post-Extraction Complications in Type II Diabetic and Non-Diabetic Patients
Abstract Objective: Prevalence of tooth loss is higher among diabetic patients in comparison with non-diabetic patients. The aim of this study was to evaluate and compare the relationship between socket blood sugar and post-extraction complications in type II diabetic and non-diabetic patients. Materials and Methods: This cross-sectional study was carried out on 80 diabetic and 80 non-dia...
متن کاملNew insights into the prevention and treatment strategies for hypertrophic scars and keloids
Hypertrophic scars and keloids are fibrosis abnormalities associated with the accumulation of collagen and extra cellular matrix components. These scars are caused by abnormal wound healing, which may occur after skin injuries caused by surgery, trauma, burns, etc. and may have a large impact on the patients’ quality of life. Hypertrophic scars and colloids in addition to aesthetic problems can...
متن کاملSugar, fat, and protein: new insights into what T cells crave
T cell activation and differentiation is a complex process that has evolved beyond the two-signal model to a number of varied and opposing inputs that must be interpreted to make a cell fate decision. While stimulation through the TCR, costimulatory, and cytokine receptors is required, metabolic signaling has emerged not only as an activation signal, but also one that can influence and shape di...
متن کاملGetting better without AGE: new insights into the diabetic heart.
Nearly a century ago, Maillard first observed that incubation of glucose with amino acids led to the formation of a yellow-brown pigment due to nonenzymatic glycosylation.1 This unstable compound known as a Schiff base can undergo rearrangement over several days to form the more stable Amadori-type product.2 One wellknown example is hemoglobin A1C, the adduct of glucose with the N-terminal vali...
متن کاملNew Insights into the Effect of Diabetes and Obesity in Alzheimer’s Disease
Abstract Alzheimer’s disease (AD) is the most common cause of dementia in elderly people. The prevalence of Alzheimer diseases is increasing in the world due to population aging. Metabolic disease such as diabetes and obesity play important role in Alzheimer disease. Hyperglycemia can play important role in brain damage. It causes cognitive impairments, functional and structural alterations in...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
biomacromolecular journalجلد ۲، شماره ۲، صفحات ۹۳-۹۶
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023