the effect of two types of garlic supplementation on dna damage resulting from exhaustive exercise in non-athlete men

the aim of this study was to investigate the effect of long-term garlic supplementation (500 and 1000 mg) on dna damage index resulting from exhaustive exercise in non-athlete students. 26 male non-athletes (mean+sd age 21±1.23 years, weight 69.38±8.28 kg and height 178.9±6.11 cm) were divided randomly into three groups: the placebo and 2 garlic supplementation groups (500 and 1000 mg/day) (the first supplementation group: n=9, the second supplementation group: n=9 and placebo group: n=8). the first and second blood samples were collected in the baseline and after the exhaustive exercise and the third and fourth samples were collected after 8 weeks of supplementation in the baseline and after the exhaustive exercise. the data were analyzed by anova with repeated measures and two-way anova (a≤0.05). the results showed that a session of exhaustive exercise significantly increased dna damage. in addition, long-term garlic supplementation (500 and 1000 mg/day) decreased dna damage in the baseline and after exhaustive exercise. also, 1000 mg garlic supplementation decreased dna damage more than 500 mg garlic supplementation in the baseline and after exhaustive exercise (p=0.01).