o27: the role of hydrogels and cell based therapies in regeneration of spinal cord injury

نویسندگان

hadi aligholi a. department of neuroscience, school of advanced medical sciences and technologies, shiraz university of medical sciences, shiraz, iran b. shefa neuroscience research center, khatam alanbia hospital, tehran, iran

mohammad torabi-nami department of neuroscience, school of advanced medical sciences and technologies, shiraz university of medical sciences, shiraz, iran

bijan zare department of medical biotechnology, school of advanced medical sciences and technologies, shiraz university of medical sciences, shiraz, iran

چکیده

spinal cord injury (sci) is one of the devastating conditions leading to functional and neurological deficits following road traffic accidents. to date, there is no definite treatment for repairing damaged spinal cord tissue. in this regard, cell therapy opens a new window in front of scientists by using different cells such as mesenchymal stem cells, olfactory ensheathing cells, schwann cells, neural stem cells and induced pluripotent stem cells. but, cell therapy faces some problems related to cell survival, migration and differentiation. based on the results of recent studies, supporting the transplanted cells with a proper scaffold can be helpful. among several scaffolds, hydrogels are outstanding one with several beneficial properties for neural tissue engineering. the future of sci regeneration is probably linked to combinatorial approaches in which both cells and scaffolds play its significant roles.

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منابع مشابه

O27: The Role of Hydrogels and Cell Based Therapies in Regeneration of Spinal Cord Injury

Spinal cord injury (SCI) is one of the devastating conditions leading to functional and neurological deficits following road traffic accidents. To date, there is no definite treatment for repairing damaged spinal cord tissue. In this regard, cell therapy opens a new window in front of scientists by using different cells such as mesenchymal stem cells, olfactory ensheathing cells, Schwann cells,...

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Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration

Spinal cord injury (SCI) is a central nervous system- (CNS-) related disorder for which there is yet no successful treatment. Within the past several years, cell-based therapies have been explored for SCI repair, including the use of pluripotent human stem cells, and a number of adult-derived stem and mature cells such as mesenchymal stem cells, olfactory ensheathing cells, and Schwann cells. A...

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عنوان ژورنال:
مجله علوم اعصاب شفای خاتم

جلد ۳، شماره ۴، صفحات ۲۷-۲۷

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