platelet-rich plasma in treatment of zoledronic acid-induced bisphosphonate-related osteonecrosis of the jaws
نویسندگان
چکیده
conclusions our study demonstrates positive results (preservation or regeneration of bone) using prp in treatment of bronj. although prp may enhance osseous regeneration, long-term follow-ups are required to confirm its benefits. background bisphosphonate-related osteonecrosis of the jaws (bronj) is a well-known challenging entity warranting management. platelet-rich plasma (prp) plays an important role in bone biology by enhancing bone repair and regeneration. objectives the aim of this animal study was to evaluate the effects of prp on zoledronic acid-induced bronj. materials and methods seven rats were given 0.04 mg zoledronic acid intravenously once a week for five weeks. two weeks later, the animals underwent extraction of their first lower molars, bilaterally. after clinical confirmation of the osteonecrosis, prp was injected randomly into one of the extraction sockets of each rat. three weeks later, all rats were sacrificed in order to obtain histological sections. the analysis of epithelialization was performed by mcnamar’s test, and the analysis of osteogenesis and angiogenesis was performed by the wilcoxon sign rank test. p value was set at 0.05. results we found no significant differences between the two groups regarding the amount of epithelialization, angiogenesis or sequestrum formation (p > 0.05), but a significant difference was seen between the two groups regarding the amount of existing vital bone (p < 0.05).
منابع مشابه
Platelet-Rich Plasma in Treatment of Zoledronic Acid-Induced Bisphosphonate-related Osteonecrosis of the Jaws
BACKGROUND Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a well-known challenging entity warranting management. Platelet-Rich Plasma (PRP) plays an important role in bone biology by enhancing bone repair and regeneration. OBJECTIVES The aim of this animal study was to evaluate the effects of PRP on zoledronic acid-induced BRONJ. MATERIALS AND METHODS Seven rats were given 0.04...
متن کاملUse of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw.
Platelet-rich plasma is a concentrate of growth factors and osteoconductive proteins, which can play a major role in bone biology by accelerating and enhancing bone repair and regeneration. This paper describes the results of using platelet-rich plasma in the management of bisphosphonate-associated necrosis of the jaw. Eight patients with a diagnosis of bisphosphonate-associated necrosis of the...
متن کاملBisphosphonate-related osteonecrosis of the jaws (Bronj)
UNLABELLED Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is an extremely therapy resistant osteomyelitis-like disease exclusively involving the jaw bones of patients in treatment with bisphosphonates (BPs). OBJECTIVES The aim of this study was to evaluate the radiological and clinical findings and management of 51 patients with BRONJ diagnosed from 2004 to 2009 in our Reference Cen...
متن کاملPlatelet Rich Plasma in the Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw: Personal Experience and Review of the Literature
Bisphosphonates (BPs) are a class of synthetic drugs commonly used to treat bone metastasis and various bone diseases that cause osseous fragility (such as osteoporosis). Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a common complication in patients who received BPs, especially intravenously. Recently, osteonecrosis of the jaw (ONJ) caused by chemotherapeutic not belonging to BPs ...
متن کاملBisphosphonate related osteonecrosis of the jaws (BRONJ) in osteoporotic males
BACKGROUND The purpose of this study was to describe the clinical characteristics of bisphosphonate related osteonecrosis of the jaws (BRONJ) in osteoporotic males. METHODS The medical records of BRONJ patients from 2007 to 2014 were reviewed. The data from only the male patients was extracted, and demographic data was collected and biochemical markers were measured. RESULTS 11 Patients out...
متن کاملBisphosphonate related osteonecrosis of the jaws: report of two cases
Bisphosphonates are compounds used to treat osteoporosis and malignant bone metastasis. Despite the benefits related to the use of these medications, osteonecrosis of the jaws is a significant complication in a subset of patients receiving these drugs. This complication occurs either spontaneously or after a simple dento-alveolar surgery. Recently there were two patients who showed the features...
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عنوان ژورنال:
trauma monthlyجلد ۱۹، شماره ۲، صفحات ۰-۰
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