"can preoperative ca-125 predict resectability of tumor in patients with advanced epithelial ovarian carcinoma?"
نویسندگان
چکیده
larger tumor burden leads to higher serum ca-125 levels and the ability to perform optimal tumor cytoreduction of advanced ovarian cancer is also a function of tumor bulk. the purpose of this study was to identify the ability of preoperative serum ca-125 to predict possibility of optimal primary tumor cytoreduction in epithelial ovarian carcinoma (eoc). a total of 90 patients with eoc were evaluated in a prospective study from 2000 to 2002. preoperative serum ca-125 levels were determined, using a solid phase immunoassay. we used a receiver operating characteristic curve to identify the ca-125 level with the maximal prognostic power in predicting optimal versus suboptimal debulking. the median ca-125 level for the 90 patients was 500 u/ml (range 13 to 5000 u/ml). seventy patient (78%) had stage iii or ιv based on staging system of the international federation of gynecology and obstetrics (figo) for ovarian carcinoma. optimal cytoreduction (diameter of largest residual tumor less than 1 cm) was obtained in 44 patients (62.9%) with stage iii-ιv. preoperative ca- 125 value less than 450 u/ml had a positive predictive value for optimal cytoreduction of 78%, but a poor negative predictive value of 50% in advanced eoc. in patients with advanced eoc, at a cutoff 450 u/ml, 78% underwent optimal debulking, whereas 50% of patients with preoperative ca-125 level above 450 u/ml were still able to undergo optimal debulking. preoperative ca-125 does not seem to be a reliable predictor of optimal cytoreduction.
منابع مشابه
Prognostic value of CA 125 in ovarian cyst fluid of patients with epithelial ovarian cancer.
Most ovarian tumors contain ovarian cyst fluid (oCF) which can be easily obtained during surgery. This is the first study that explored if CA 125 in oCF could be of prognostic value for patients with epithelial ovarian cancer (EOC). Of 54 patients with primary EOC, oCF and preoperative serum were collected and clinicopathological data were retrospectively obtained. CA 125 was measured with the ...
متن کاملA longitudinal analysis with CA-125 to predict overall survival in patients with ovarian cancer
OBJECTIVE The objective of this study was to explore the association of longitudinal CA-125 measurements with overall survival (OS) time by developing a flexible model for patient-specific CA-125 profiles, and to provide a simple and reliable prediction of OS. METHODS A retrospective study was performed on 275 patients with ovarian cancer who underwent at least one cycle of primary chemothera...
متن کاملCan CA-125 Predict Lymph Node Metastasis in Epithelial Ovarian Cancers in Turkish Population?
OBJECTIVE The role of single preoperative serum CA-125 levels in predicting pelvic or paraaortic lymph node metastasis in patients operated for epithelial ovarian cancer has been investigated. METHODS 176 patients diagnosed with epithelial ovarian carcinoma after staging laparotomy between January 2002 and May 2010 were evaluated retrospectively. RESULTS The mean, geometric mean, and median...
متن کاملPrediction of a high-risk group based on postoperative nadir CA-125 levels in patients with advanced epithelial ovarian cancer
OBJECTIVE We aimed to determine the ideal cut-off of nadir serum CA-125 level for prediction of progression free survival. METHODS Among 267 patients who achieved complete remission after chemotherapy, the correlation between nadir CA-125 and progression free survival were compared among the subgroups classified according to the distribution of CA-125. The diagnostic odds ratio and area under...
متن کاملPrognostic value of serum CA-125 in patients with advanced epithelial ovarian cancer followed by complete remission after adjuvant chemotherapy
OBJECTIVE The aim of this study was to evaluate the prognostic value of serum CA-125 in advanced epithelial ovarian cancer with complete remission after primary adjuvant chemotherapy. METHODS We reviewed the records of 120 patients with advanced epithelial ovarian cancer who underwent primary surgery followed by adjuvant therapy at our institution between January 1998 and December 2005. RES...
متن کاملThe Value of CA 125 and CA72-4 in Management of Patients with Epithelial Ovarian Cancer
UNLABELLED The role of the tumor markers CA125 and CA72-4 has been evaluated in the diagnosis and management of ovarian cancer. Both markers were measured in 30 patients with proven epithelial ovarian cancer, 30 patients with benign pelvic masses and 30 normal women. CA125 and CA72-4 were measured using the luminometric immunoassay and immunoradiometric assay respectively. All patients with ova...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
acta medica iranicaجلد ۴۲، شماره ۶، صفحات ۴۱۹-۴۲۳
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023