the protective effect of the methanolic extract of ferula persica in rat tongue neoplasm (oral squamous cell carcinoma) induced by 4-nitroquinoline-1-oxide (4-nqo)
نویسندگان
چکیده
background cancer is one of the most significant causes of death around the world, and oral squamous cell carcinoma (oscc) represents 90% of oral malignancies. ferula persica has been used for treatment of different diseases in iranian traditional medicine. previous studies reveal some evidence relating to the value of preventing malignancies through f. persica. objectives the aim of the present study was to evaluate the protective effect of methanolic extract of ferula persica in rat tongue neoplasm induced by 4-nitroquinoline-1-oxide (4-nqo). materials and methods this experimental study was carried out in the pharmaceutical research center in tabriz, iran. according to ethical considerations, the results of the pilot study (five rats in each group) and pathologic changes in 30% of cases with considering α = 5%, p = 80%, and d = 5%, 15 samples for each group were determined. in this study, the oscc was induced by 4-nqo in 60 sd rats (in four groups). at the same time, three groups of rats received ferula persica methanolic extract (fpme) intraperitoneally (ip) in the doses 50, 250, and 500 mg per kilogram of body weight twice each week for 14 weeks. conclusions the results showed that the fpme prevented the progress of the malignancy in the oscc model in rats. however, further investigations are necessary to clarify effective fractions, mode of action of the fpme, and its potential therapeutic application in different types of cancer. results the obtained weight differences between groups were not significant (p = 0.18). pathological changes in the treated and non-treated groups were significantly different (p < 0.001). after treatment, pathologic changes were seen in groups a, b, c, and d (the cancer control group) respectively as follows: mild dysplasia - 13.3%, 26.7%, 20%, and 0.0%; moderate dysplasia - 33.3%, 13.3%, 40%, and 0.0%; severe dysplasia - 33.3%, 40%, 26.7%, and 0.0%; carcinoma in situ - 6.7%, 13.3%, 6.7%, and 20%; and squamous cell carcinoma - 13.3%, 6.7%, 6.7%, and 80%.
منابع مشابه
the effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولEffects of sex hormones on rat tongue carcinoma induced by 4-nitroquinoline 1-oxide (4NQO).
We investigated the regulatory effects of sex hormones on tongue carcinoma initiated by orally administration 4-nitroquinoline 1-oxide (4NQO) to rats. Animals of either sex were classified into three groups. The male rats in each group received an estrogen administration (Me), orchiectomy (Mor), or both treatments (Me/or) while the female rats also received testosterone administration (Ft), ova...
متن کاملChemopreventive effect of green tea catechin on rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide
Treatments for oral cancer may have significant adverse effect on the patient’s activities of daily living (ADL) and quality of life (QOL). However, foods may offer potential for chemoprevention. In recent years, attention has been focused on the anti-tumor and carcinogenesis-inhibiting actions of green tea. (−)Epigallocatechin-3-gallate (EGCG), the main component of green tea catechins, has be...
متن کاملImbalance of tumor suppression genes expression following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
This study was undertaken to investigate, by immunohistochemistry, the expression of some tumor suppressor genes such as p16, p21 and Retinoblastoma (Rb) during 4-Nitroquinoline 1-oxide induced rat tongue carcinogenesis. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12 or 20 weeks. Ten animals wer...
متن کاملassessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
چکیده ندارد.
15 صفحه اولQuantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat.
The incidence of tongue carcinomas (TCs) induced by oral administration of 4-nitroquinoline 1-oxide in rats is strain dependent. The inbred Dark-Agouti (DA) strain showed a much higher susceptibility to large mass-forming infiltrative TCs than did the Wistar-Furth (WF) strain. Our previous study (M. Kitano et al, Jpn. J. Cancer Res., 87: 1097-1101, 1996) on crosses between these two strains pos...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian red crescent medical journalجلد ۱۸، شماره ۱۲، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023