the comparison of procalcitonin guidance administer antibiotics with empiric antibiotic therapy in critically ill patients admitted in intensive care unit

The Comparison of Procalcitonin Guidance Administer Antibiotics with Empiric Antibiotic Therapy in Critically Ill Patients Admitted in Intensive Care Unit.

The empiric antibiotic therapy can result in antibiotic overuse, development of bacterial resistance and increasing costs in critically ill patients. The aim of the present study was to evaluate the effect of procalcitonin (PCT) guide treatment on antibiotic use and clinical outcomes of patients admitted to intensive care unit (ICU) with systemic inflammatory response syndrome (SIRS). A total o...

Comparison of the effect of Coenzyme Q10 and N-acetyl cysteine in prevention of acute kidney disease in critically ill patients admitted to Pediatric Intensive Care Unit

Background: Acute renal injury (AKI) is one of the most common causes of mortality in children admitted to intensive care units (PICU). Here, we investigated the preventive effect of N-acetylcysteine ​​(NAC) and Coenzyme Q10 on AKI among children admitted to PICU. Methods: This double-blind randomized clinical trial study was done on 78 children admitted to PICU in 2018. Patients were randomly...

Association between admission hypomagnesemia mortality or mortality of critically ill patients in intensive care unit

Background: Up to now there is no study evaluating correlation between serum magnesium and morbidity or mortality in patients admitted in intensive care unit. The aim of this study is to determine the prevalence of hypomagnesemia in critically ill patients and to evaluate its association with organ dysfunction, hospitalization period and mortality. Methods: We conducted a retrospective trial ...

Early procalcitonin kinetics and adequate empiric antibiotic therapy in critically ill

Procalcitonin for antibiotic treatment in intensive care unit patients.

Procalcitonin (PCT), a 116-aminoacids prohormone, has been substantially studied over the last 2 decades in the field of sepsis. Disappointingly low sensitivity values led to the abandonment of the concept of it as a diagnostic tool and then to its being considered more as a prognostic marker with a good correlation with severe infection. Later on, growing concerns about multidrug-resistant bac...

Procalcitonin-guided antibiotic therapy for septic patients in the surgical intensive care unit

In critically ill patients, elucidating those patients with the systemic inflammatory response syndrome (SIRS) from an infectious source (sepsis), versus those who have SIRS without infection, can be challenging since the clinical features are the same. Even with strict monitoring and testing, 39-98 % of patients with SIRS will never have bacteriological confirmation of an infection, and 6-17 %...