immunohistochemical study of her2/neu overexpression in adenoid cystic carcinoma of salivary glands
نویسندگان
چکیده
background and objectives: adenoid cystic carcinoma (acc), the most common malignant tumor of submandibular and minor salivary glands, is characterized by a high rate of local recurrence and distant hematogenous metastasis and tendency to invade peripheral nerves. in spite of radiotherapy and surgical treatment, the long-term prognosis is dismal. today, many studies are being conducted using the immunohistochemical markers to help in the evaluation of acc prognosis. the present investigation was performed to survey immunohistochemically her2/neu over expression in adenoid cystic carcinoma of salivary glands. materials and methods: the 24 existing samples of formalin-fixed paraffin embedded specimen were stained with her2/neu markers. tumors with moderate (2+) to strong (3+) complete membrane staining in at least 10% of the tumor cells were scored as positive for over expression. results: the overall frequency of over expression for her2/neu was 45.8% and 11 specimen were positive for her2/neu expression. a significant relationship was found between her2/neu over expression and grade of acc. no significant relationship was detected between immunostaining of her2/neu and histologic pattern. conclusion: her2/neu immunostaining might be reliable and useful for evaluation of acc prognosis.
منابع مشابه
Immunohistochemical Study of HER2/neu Overexpression in Adenoid Cystic Carcinoma of Salivary Glands
Background and Objectives: Adenoid cystic carcinoma (ACC), the most common malignant tumor of submandibular and minor salivary glands, is characterized by a high rate of local recurrence and distant hematogenous metastasis and tendency to invade peripheral nerves. In spite of radiotherapy and surgical treatment, the long-term prognosis is dismal. Today, many studies are being conducted using...
متن کاملImmunohistochemical Assessment of Ki-67 Expression in Adenoid Cystic Carcinoma of the Salivary Glands
Objective Adenoid cystic carcinoma (ACC) is a rare malignant tumor originating from the salivary glands. It’s rather bland histological appearance that masks its ultimate biological aggressiveness. Evaluation of cell cycle and mitoses have been useful in predicting malignancy in many tumors. Ki-67 antigen is a human nuclear antigen that presents during all active phases of cell cycle. The aim ...
متن کاملAdenoid cystic carcinoma of the salivary glands.
Eighty-two patients with adenoid cystic carcinoma treated by a radical course of radiotherapy are reviewed. In 44 cases the tumour arose in the major salivary glands and, of these, 77% had an incomplete surgical excision and 23% had only a tumour biopsy before radiotherapy. Thirty-eight tumours arose in the minor salivary glands and, of these, 18% had an incomplete surgical excision and 82% a b...
متن کاملimmunohistochemical assessment of ki-67 expression in adenoid cystic carcinoma of the salivary glands
objective adenoid cystic carcinoma (acc) is a rare malignant tumor originating from the salivary glands. it’s rather bland histological appearance that masks its ultimate biological aggressiveness. evaluation of cell cycle and mitoses have been useful in predicting malignancy in many tumors. ki-67 antigen is a human nuclear antigen that presents during all active phases of cell cycle. the aim o...
متن کاملImmunohistochemical Assessment of Ki-67 Expression in Adenoid Cystic Carcinoma of the Salivary Glands
Objective Adenoid cystic carcinoma (ACC) is a rare malignant tumor originating from the salivary glands, the rather bland histological appearance of which masks its ultimate biological aggresiveness. Evaluation of cell cycle and mitoses has been useful in predicting malignancy in many tumors. Ki-67 antigen is a human nuclear antigen that appears in all active phases of cell cycle. The study has...
متن کاملMitochondrial Mutations in Adenoid Cystic Carcinoma of the Salivary Glands
BACKGROUND The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas. METHODOLOGY The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was s...
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عنوان ژورنال:
iranian journal of pathologyناشر: iranian society of pathology
ISSN 1735-5303
دوره 6
شماره 2 2011
کلمات کلیدی
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