imatinib loaded pegylated poly propylene imine dendrimer for delivery to leukemic cells; fabrication of formulation and evaluation

نویسندگان

ramadoss karthikeyan

department of biotechnology, acharya nagarjuna university, nagarjuna nagar, guntur-522510 india. palanirajan vijayraj kumar

faulty of pharmaceutical sciences, ucsi university, kualalampur, malaysia. oruganti sai koushik

vignan pharmacy college, vadlamudi – 522213, india.

چکیده

pegylated polypropyleneimine (ppi) dendritic scaffold was used for the delivery of an anti-leukemic drug, imatinib. the current study evolves and emerges the use pegylated ppi dendritic scaffold for the delivery of this drug. in this imatinib was synthesized and loaded with pegylated ppi dendritic scaffold. parameters such as ft-ir, nmr, sem, drug release, dsc and hemolytictoxicity are required. other parameters such as drug entrapment of both pegylated and non-pegylated systems were comparatively determined. drug-loading capacity was found to be increased with the pegylation and reduces the haemolytic toxicity as well as drug release rate. by this, prolonged delivery of imatinib was found to be suitable with this system. by delivering the drug for a prolonged period of time at a controlled rate, we expect that this approach will improve the management of drug therapy in leukemic patients.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Imatinib loaded pegylated Poly Propylene Imine dendrimer for delivery to leukemic cells; fabrication of formulation and evaluation

PEGylated polypropyleneimine (PPI) dendritic scaffold was used for the delivery of an anti-leukemic drug, Imatinib. The current study evolves and emerges the use PEGylated PPI dendritic scaffold for the delivery of this drug. In this Imatinib was synthesized and loaded with PEGylated PPI dendritic scaffold. Parameters such as FT-IR, NMR, SEM, drug release, DSC and hemolytictoxicity are required...

متن کامل

Imatinib loaded pegylated Poly Propylene Imine dendrimer for delivery to leukemic cells; fabrication of formulation and evaluation

PEGylated polypropyleneimine (PPI) dendritic scaffold was used for the delivery of an anti-leukemic drug, Imatinib. The current study evolves and emerges the use PEGylated PPI dendritic scaffold for the delivery of this drug. In this Imatinib was synthesized and loaded with PEGylated PPI dendritic scaffold. Parameters such as FT-IR, NMR, SEM, drug release, DSC and hemolytictoxicity are required...

متن کامل

Poly(propylene imine) dendrimer caps on mesoporous silica nanoparticles for redox-responsive release: smaller is better.

To elucidate the importance of the size of capping agents in stimulus-induced release systems from mesoporous silica nanoparticles (MSNs), the effectiveness of poly(propylene imine) dendrimers in controlling the model drug release was studied. MCM-41-type MSNs were synthesized and characterized. Fluorescent compounds (fluorescein disodium salt and carboxyfluorescein) were loaded in the porous s...

متن کامل

Salt-free dyeing of cotton fabric modified with prepared chitosan-poly propylene imine dendrimer using direct dyes

This study presents a novel method for eco-friendly dyeing of cotton fabrics with direct dyes. Cotton fabric modified with chitosan-poly propylene imines dendrimer CS-PPI, and its dyeing and fastness properties were investigated using three direct dyes. The impacts of important factors, i.e., CS-PPI concentration, dye concentration, dyeing time, dyeing temperature, and salt concentration were i...

متن کامل

Evaluation of Gd(III)DTPA-terminated poly(propylene imine) dendrimers as contrast agents for MR imaging.

Different generations of Gd(III)DTPA-terminated poly(propylene imine) dendrimers {G1 [n = 4 Gd(III) ions per molecule], G3 (n = 16) and G5 (n = 64)} and reference Gd(III)DTPA complex [G0 (n = 1)] were characterized in terms of (i) longitudinal (r1) and transverse (r2) relaxivities in mouse blood plasma, (ii) concentration detection limits in vitro and (iii) in vivo contrast-enhanced MR imaging ...

متن کامل

Formulation, and Evaluation of Pentoxifylline-Loaded Poly(ε-caprolactone) Microspheres

Pentoxifylline-loaded poly(epsilon-caprolactone) microspheres were prepared by solvent evaporation technique with different drug to carrier ratio F1 (1:3), F2 (1:4), F3 (1:5) and F4 (1:6). The microspheres were characterized for particle size, scanning electron microscopy, FT-IR study, percentage yield, drug entrapment, stability studies and for in vitro release kinetics. The shape of microsphe...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
international journal of nano dimension

جلد ۷، شماره ۴، صفحات ۳۳۶-۳۴۸

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023