antibacterial effects of bismuth compounds and it synergy with tetracycline and metronidazole on helicobacter pylori

bismuth salts and different antimicrobials including metonidazole & tetracyclines were used in the assessment of inhibition zone of helicobacter pylori cultures on solid media. antibiotics were used or in combined in order to find out their possible synergistic effects. it was showed that: only bismuth substrate and not then salts have antibacterial effects on helicobacter pylori and also on the other bacteria such as staphylococci salmonella and brulla. in addition, only bismuth substrances showed remarkable synergistic effects with antimicrobial drugs against helicobacter pylori. therefore the data obtained from this investigation confirm previously known effect of combination antibiotic therapy including bismuth compounds in eradicating helicobacter pylori.