optimization of in-vitro permeation pattern of ketorolac tromethamine transdermal patches

the present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (pvp) and ethyl cellulose (ec) using a d-optimal mixture design. the prepared transdermal patches were subjected to different physicochemical evaluation. the surface topography of the patches was examined by scanning electron microscopy (sem). the drug-polymer interaction studies were performed using fourier transform infrared spectroscopic (ftir) technique. a correlation between in-vitro drug-release and in-vitro skin permeation was established and the criterion of desirability was employed to optimize the formulation. the results of the physicochemical characterization and in-vitro permeation of the prepared patches were promising to formulate transdermal patches with pvp/ec combinations.