synthetic studies in the 6h-[1,2,4] triazino [3,4-b] [ 1,3,4] thiadiazines

SYNTHETIC STUDIES IN THE 6H-[1,2,4] TRIAZINO [3,4-b] [ 1,3,4] THIADIAZINES

4-Amino-6-methyl- 1,2,4-triazine-3(2H)-thione-5-0ne (1) was condensed with propargyl bromidein the presence of sodium rnethoxide to afford 3-propargylmercapto- 4-arnino-6-rnethyl-1,2,4-triazin-5-one(2) . Transformation of the latter to 8-dihydro- 3-methyl-7-methylene-4-oxo-6H-[1,2,4]TRIAZINO [3,4-b] [1,3,4] thiadiazine (3) was performed under the condition of palladium (II) salt. Ring closu...

Dibenzo[b,e]thiepin-11(6H)-one

In the title compound, C(14)H(10)OS, the seven-membered thiepin ring adopts a distorted boat conformation with the dihedral angle between the mean planes of the two fused benzene rings being 56.5 (1)°.

SYNTHESIS AND STRUCTURE ELUCIDATION OF 1,2,4-TRIAZINO [4,3-b] 1,2,4-TRIAZINES, 1,2,4-TRIAZINO [3,4-C] 1,2,4-TRIAZINES AND 1,2,4-TRIAZINO [4,3-dl l,2,4-TRIAZINES

Aruncin B: Synthetic Studies, Structural Reassignment and Biological Evaluation

A ring-closing alkene metathesis (RCM)/ oxyselenation-selenoxide elimination sequence was established to the sodium salts E- and Z-25 of the originally proposed structure for the recently isolated cytotoxin aruncin B (1), as well as to the sodium salt Z-34 of a related ethyl ether regioisomer; however, none of their corresponding free acids could be obtained. Their acid sensitivity, together wi...

Development of the dipole strength distribution with increasing nuclear deformation - study of the isotopes 124 Xe and 134

6H,12H-5,11-Ethano­dibenzo[b,f][1,5]diazo­cine

In the mol-ecule of the title compound, C(16)H(16)N(2), the ethano-strapped analogue of unsubstituted Tröger's base, the dihedral angle between the two benzene rings is 75.85 (4)°, the smallest angle measured for an ethano-strapped analogue.