uv-visible spectrophotometry of repaglinide in bulk and in formulation by using methyl orange as reagents
نویسندگان
چکیده
two sensitive spectrophotometric methods are presented for the assay of repaglinide in bulkdrug and in formulations using methyl orange, as reagents. oxidant by reacting with a fixedamount of either methyl orange and measuring the absorbance at 485.2 nm (method-i) andmeasuring the absorbance at 618.9 nm (method-ii). developed method is based on the formationof extractable colored complex of drug with coloring agent methyl orange dye. a wavelengthmaximum was found to be 618.9 nm. the concentration range of 15-50 μg ml-1 with linearregression of 0.9995, while the percentage recovery, lod and loq were 99.42-99.08 %, 2.17μg ml-1 and 1.08 μg ml-1 respectively. the result of analysis have been validated statistically andalso by recovery studies. from the percentage recovery and specificity studies it was concludedthat there was no interference of common additives during the estimation. this proves thesuitability of this method for the routine quality control analysis of the repaglinide informulation.
منابع مشابه
UV-Visible spectrophotometry of Repaglinide in bulk and in formulation by using methyl orange as reagents
Two sensitive spectrophotometric methods are presented for the assay of Repaglinide in bulkdrug and in formulations using methyl orange, as reagents. Oxidant by reacting with a fixedamount of either methyl orange and measuring the absorbance at 485.2 nm (method-I) andmeasuring the absorbance at 618.9 nm (method-II). Developed method is based on the formationof extractable colored complex of dru...
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عنوان ژورنال:
journal of the iranian chemical researchجلد ۴، شماره ۲، صفحات ۶۹-۷۶
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