accuracy of magnetic resonance spectroscopy in distinction between radiation necrosis and recurrence of brain tumors.
نویسندگان
چکیده
background: distinction between radiation necrosis and recurrence of intraparenchymal tumors is necessary to select the appropriate treatment, but it is often difficult based on imaging features alone. we developed an algorithm for analyzing magnetic resonance spectroscopy (mrs) findings and studied its accuracy in differentiation between radiation necrosis and tumor recurrence. m e t hod s : thirty-three patients with a history of intraparenchymal brain tumor resection and radiotherapy, which had developed new enhancing lesion were evaluated by mrs and subsequently underwent reoperation. lesions with choline (cho)/n- acetyl aspartate (naa) > 1.8 or cho/lipid > 1 were considered as tumor recurrence and the remaining as radiation necrosis. finally, pre-perative mrs diagnoses were compared with histopathological report. r es u l t s : the histological diagnosis was recurrence in 25 patients and necrosis in 8 patients. mean cho/naa in recurrent tumors was 2.72, but it was 1.46 in radiation necrosis (p < 0.01). furthermore, cho/lipid was significantly higher in recurrent tumors (p < 0.01) with the mean of 2.78 in recurrent tumors and 0.6 in radiation necrosis. sensitivity, specificity, and diagnostic accuracy of the algorithm for detecting tumor recurrence were 84%, 75% and 81%, respectively. conclusion: mrs is a safe and informative tool for differentiating between tumor recurrence and radiation necrosis.
منابع مشابه
Accuracy of magnetic resonance spectroscopy in distinction between radiation necrosis and recurrence of brain tumors
BACKGROUND Distinction between radiation necrosis and recurrence of intraparenchymal tumors is necessary to select the appropriate treatment, but it is often difficult based on imaging features alone. We developed an algorithm for analyzing magnetic resonance spectroscopy (MRS) findings and studied its accuracy in differentiation between radiation necrosis and tumor recurrence. METHODS Thirty...
متن کاملComparison of brain SPECT with 99mTc-MIBI and CT-scan in discriminating of radiation necrosis and brain tumor recurrence [Persian]
Introduction: 99mTc-MIBI has been proposed for use as an imaging agent for various tumors, including breast cancer, lung cancer, lymphomas, melanomas and brain neoplastic lesions. Brain tumors are very common and radiotherapy being major part of treatment following surgery. After radiotherapy, deteriorating clinical status can be due to either radiation necrosis or recurrent tumor. Comput...
متن کاملMultivoxel magnetic resonance spectroscopy of brain tumors.
Magnetic resonance spectroscopy (MRS) is becoming more widely available for clinical applications and is able to provide information about the metabolic properties of regions of normal and abnormal tissue morphology. A critical question for the clinical management of patients with brain tumors is whether multivoxel MRS is able to add new information to the high-quality anatomical data provided ...
متن کاملproton Magnetic resonance spectroscopy in Differential Diagnosis of brain tuMors
The aim of the investigation was to assess the informativity of proton magnetic resonance spectroscopy (PMRS) data in differentiation of brain tumors and nonneoplastic diseases with similar signal characteristics on standard MRI scans, as well as glioma grade determination. Materials and Methods. We examined 45 patients aged from 25 to 56 years with suspected expansive process of brain using pr...
متن کاملThe use of 1H-magnetic resonance spectroscopy in studying radiation-induced injury of the brain in elderly and young patients with nasopharyngeal carcinoma
Background: This study aims to investigate the metabolic characteristics of radiotherapy-induced temporal lobe injury in elderly patients with nasopharyngeal carcinoma using 1H-magnetic resonance spectroscopy (MRS). Materials and Methods: Data were collected from 21 elderly patients and 33 young patients before and during therapy with different radiation dosages (2...
متن کاملP63: Automatic Detection of Glioblastoma Multiforme Tumors Using Magnetic Resonance Spectroscopy Data Based on Neural Network
Inflammation has been closely related to various forms of brain tumors. However, there is little knowledge about the role of inflammation in glioma. Grade IV glioma is formerly termed glioblastoma multiform (GBM). GBM is responsible for over 13,000 deaths per year in the America. Magnetic resonance imaging (MRI) is the most commonly used diagnostic method for GBM tumors. Recently, use of the MR...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of neurologyجلد ۱۴، شماره ۱، صفحات ۲۹-۳۴
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023