effects of lithium carbonate on apomorphine-induced sniffing behaviour in rats

نویسندگان

یحیوی سیدحسین

yahyavi hossein department of anesthesiology, islamic azad university, tehran medical unitگروه بیهوشی، دانشگاه آزاداسلامی، واحد پزشکی تهران فضلی طبایی سهیلا

fazli tabaie soheila department of physiology, islamic azad university, tehran medical unitگروه فیزیولوژی، دانشگاه آزاداسلامی، واحد پزشکی تهران زرین دست محمدرضا

zarrindast mohammad reza department of pharmacology, tehran university of medical sciencesگروه فارماکولوژی، دانشگاه علوم پزشکی تهران

چکیده

background: therapeutic effects of lithium in manic-depressive disorders have been clarified. during the present study, the effects of lithium carbonate have been assessed on apomorphine-induced sniffing in rats. materials and methods: male albino rats were housed in a glass cylinder and food and water were freely available till 60 minutes before the experiment. immediately after apomorphine injection the sniffing behaviour was observed directly for 60 minutes. sniffing was scored every 15 seconds. according to the following scale: 0=absent, 1=sniffing. results: intraperitoneal (ip) administration of different doses of apomorphine (0.25,0.5 and 1mg/kg) induced a dose-dependent sniffing response. chronic lithium carbonate exposure (0.1% in drinking water for 30-35 days) but not acute administration of the drug (320 mg/kg, ip) decreased the response of apomorphine. administartion of d1 dopamine receptor antagonist,sch-23390 (0.01mg/kg, ip) or the d2 dopamine receptor antagonist, sulpiride (25mg/kg, ip) did not accompany alteration in apomorphine response in rats treated with acute lithium carbonate. in animals treated chronically with lithium carbonate the blockade of apomorphine response by sulpiride but not sch23390 was potentiated. conclusion: it is concluded that chronic treatment of animals with lithium carbonate is able to alter d2 dopamine receptors response.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

The Perinatal Effects of Lithium Carbonate on Hypothalamic-Pituitary-Gonadal in Adult Female Wistar Rats

Background & Objectives: Lithium is the metal used in bipolar disorder treatment.  As for the prevalence of the disorder infertility (childbearing) age and the use of lithium, this study aimed at studying the effects of drugs on histological changes, and the ovarian function in the first generation of adult female offspring was performed. Materials & Methods: In this experimental study, 40 pre...

متن کامل

The effects of Adrenergic agents on the dopaminergic-induced sniffing

  There is evidence indicating that adrenoceptor mechanisms may influence some of the behaviors in rat. However the role of adrenoceptor agents on sniffing has not been identified. In the present study, the influence of adrenoceptor agents on sniffing induced by apomorphine and amphetamine has been investigated. Male Albino rats, weighing 150-250 g were used for all experiments. The behavior wa...

متن کامل

Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats

Patients who seek dental treatment may have bipolar disorder, and lithium carbonate (LC) is the drug of choice used in the treatment of this disorder. Taking into consideration the controversial results found in the literature, and the possible influence of LC on induced tooth movement, the objective was to evaluate tooth movement induced in rats after administration of lithium carbonate. One h...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران

جلد ۱۴، شماره ۲، صفحات ۷۵-۸۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023