natural kaolin as an efficient recyclable catalyst for the synthesis of new 2,4-disubstituted quinolines
نویسندگان
چکیده
substituted 2, 4- diphenyl quinolines were synthesized by a multicomponent domino reaction of anilines, aldehydes and terminal aryl alkynes. the synthetic pathway involves the formation of an imine, followed by the intermolecular addition of an alkyne to the imine. this intermediate immediately undergoes ring closure and oxidative aromatization. the reaction is catalyzed by natural kaolin, a strong, environmentally benign solid acid. in this procedure natural kaolin is used without any supporting. this catalyst- assisted microwave irradiation has oxidizing ability that leads to aromatization of final intermediate and produces the aromatic substituted quinolines without any other oxidizing agents. the multicomponent approach yields the products in excellent yields in a matter of minutes. the use of microwave activation reduces the reaction time significantly. no side-products are formed significantly. in addition one of the synthesized substituted quinolines is a new compound. however, this catalyst can be used for the synthesis of a variety of important heterocycles such as pyrrazoles, oxazolines, benzodiazepines and quinoxalines.
منابع مشابه
Natural kaolin as an efficient recyclable catalyst for the synthesis of new 2,4-disubstituted quinolines
Substituted 2, 4- diphenyl quinolines were synthesized by a multicomponent domino reaction of anilines, aldehydes and terminal aryl alkynes. The synthetic pathway involves the formation of an imine, followed by the intermolecular addition of an alkyne to the imine. This intermediate immediately undergoes ring closure and oxidative aromatization. The reaction is catalyzed by natural kaolin, a st...
متن کاملNatural kaolin as an efficient recyclable catalyst for the synthesis of new 2,4-disubstituted quinolines
Substituted 2, 4- diphenyl quinolines were synthesized by a multicomponent domino reaction of anilines, aldehydes and terminal aryl alkynes. The synthetic pathway involves the formation of an imine, followed by the intermolecular addition of an alkyne to the imine. This intermediate immediately undergoes ring closure and oxidative aromatization. The reaction is catalyzed by natural kaolin, a st...
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چکیده ندارد.
Phosphotungstic acid: an efficient, cost-effective and recyclable catalyst for the synthesis of polysubstituted quinolines.
Phosphotungstic acid (H(3)PW(12)O(40)) was used as an efficient and recyclable catalyst for the synthesis of polysubstituted quinolines through the Friedländer condensation of 2-aminoarylketone with carbonyl compounds, which was achieved by conventional heating under solvent-free conditions.
متن کاملKaolin-SO3H as an efficient catalyst for one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles
Kaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, anti...
متن کاملKaolin-SO3H as an efficient catalyst for one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles
Kaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, anti...
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عنوان ژورنال:
iranian journal of catalysisناشر: islamic azad university, shahreza branch
ISSN 2252-0236
دوره 6
شماره 1 2016
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