autologous marrow transplantation in the treatment of mopp and abvd-resi stant hodgkin's disease

six patients with disseminated hodgkin's disease resistant to mopp (mechlorethamine, vincristine, procarbazine and prednisolone), and abvd (adriamycin, bleomycin, vinblastine and dacarbazine) chemotherapy were treated with high-dose chemotherapy and autologous marrow transplantation. the patients first underwent marrow aspiration and storage for subsequent autologous bone marrow transplantation (ab mt). three patients remain alive in unmaintained complete remission (cr) at i x, 17, and 15 months after transplant. in the other three patients, reasons for faijure included relapse in two patients after 7 and g months, and death after 6 months due to pulmonary infection (pneumonia). these results demonstrate that some patients with mopp, abvd and other salvage chemotherapy (sc)-resistant hodgkin's disease can obtain prolonged complete remission following intensive chemotherapy and autologous marrow transplantation