new insight into the application of outer membrane vesicles of gram-negative bacteria

نویسندگان

a fateh mycobacteriology and pulmonary research department, pasteur institute of iran. tehran, iran, microbiology research center (mrc), pasteur institute of iran, tehran, iran

f vaziri mycobacteriology and pulmonary research department, pasteur institute of iran. tehran, iran, microbiology research center (mrc), pasteur institute of iran, tehran, iran

f rahimi janani mycobacteriology and pulmonary research department, pasteur institute of iran. tehran, iran, microbiology research center (mrc), pasteur institute of iran, tehran, iran

s ahmadi badi mycobacteriology and pulmonary research department, pasteur institute of iran. tehran, iran

چکیده

this review presents a brief outline of our current knowledge of the structure and chemical composition of the outer membrane vesicles (omvs), originating from the surface of gram negative bacteria including their outer membrane proteins and lipopolysaccharides. moreover, the functional roles and applications of omvs in medical research such as omv-based vaccines, omv adjuvants properties, omv carriers in conjugated vaccines as well as in drug vehicles and delivery systems are discussed. finally, new applications of these macromolecules as biotechnological tools are briefly presented.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

New insight into the application of outer membrane vesicles of Gram-negative bacteria

This review presents a brief outline of our current knowledge of the structure and chemical composition of the outer membrane vesicles (OMVs), originating from the surface of Gram negative bacteria including their outer membrane proteins and lipopolysaccharides. Moreover, the functional roles and applications of OMVs in medical research such as OMV-based vaccines, OMV adjuvants properties, OMV ...

متن کامل

The Outer Membrane of Gram-negative Bacteria and the Cytoplasmic Membrane The Outer Membrane of Gram-Negative Bacteria

The major permeability barrier in any membrane is the lipid bilayer structure, and its barrier property is inversely correlated with its fluidity. Bacteria cannot make this membrane much less fluid or it will start to interfere with the normal functions of the membrane proteins, so some bacteria have constructed an additional structure that surrounds the cell outside the cytoplasmic membrane. A...

متن کامل

A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria

Bacterial outer membrane vesicles (OMVs) have important biological roles in pathogenesis and intercellular interactions, but a general mechanism of OMV formation is lacking. Here we show that the VacJ/Yrb ABC (ATP-binding cassette) transport system, a proposed phospholipid transporter, is involved in OMV formation. Deletion or repression of VacJ/Yrb increases OMV production in two distantly rel...

متن کامل

On the origin of membrane vesicles in gram-negative bacteria.

It is proposed that the genesis of extracellular membrane vesicles in Gram-negative bacteria is a result of cell wall turnover. Peptidoglycan turnover would cause a turgor on the outer membrane, causing the outer membrane to bulge and finally bleb. Mechanical motion would then shear the blebs into the culture medium.

متن کامل

Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response

Conditions that impair protein folding in the Gram-negative bacterial envelope cause stress. The destabilizing effects of stress in this compartment are recognized and countered by a number of signal transduction mechanisms. Data presented here reveal another facet of the complex bacterial stress response, release of outer membrane vesicles. Native vesicles are composed of outer membrane and pe...

متن کامل

Outer Membrane Vesicles (OMVs) of Gram-negative Bacteria: A Perspective Update

Outer Membrane Vesicles (OMVs) of Gram-negative bacteria are spherical membrane-enclosed entities of endocytic origin. Reported in the consortia of different bacterial species, production of OMVs into extracellular milieu seems essential for their survival. Enriched with bioactive proteins, toxins, and virulence factors, OMVs play a critical role in the bacteria-bacteria and bacteria-host inter...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
vaccine research

جلد ۲، شماره ۵، صفحات ۹۳-۹۶

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023