absence of immune response as a sign of tissue tolerance in small-cell lung cancer

نویسندگان

antonio manenti department of medical and surgical sciences, section of surgery, university of modena and reggio emilia, modena, italy

luca roncati department of diagnostic and clinical medicine and public health, section of pathology, university of modena and reggio emilia, modena, italy; department of diagnostic and clinical medicine and public health, section of pathology, university of modena and reggio emilia, policlinic hospital, largo del pozzo st., 71, i-41124, modena, italy. tel: +39-594224812, fax: +39-594224997

pamela sighinolfi department of diagnostic and clinical medicine and public health, section of pathology, university of modena and reggio emilia, modena, italy

giuseppe barbolini department of diagnostic and clinical medicine and public health, section of pathology, university of modena and reggio emilia, modena, italy

چکیده

background the attention of the scientific community has been recently focused on the role of tumor-infiltrating lymphocytes in non-small-cell cancer and there is a convergence of results, supporting a direct proportionality between lymphocytic infiltrate and good prognosis. objectives the aim of our research was to investigate the immune response around and inside the small-cell lung neoplastic tissue and its related neo-lymphangiogenesis in a group of 20 patients. materials and methods we have examined 20 bioptic samples of small cell lung cancer, obtained from 18 men and two women, aged 56-74 years old. besides hematoxylin-eosin staining, immunohistochemistry for neuroendocrine markers (cd56, chromogranin) and d2-40 was performed following the standard protocols. results our histological analysis, in all cases, has emerged the absence of an immune response supported by an adequate neo-lymphangiogenesis inside the neoplasia. conclusions the absence of an immune response is interpreted as a sign of tissue tolerance and host acceptance towards the cancer, in favor of the cancer metastatic spread. the development of a paraneoplastic syndrome can be considered a biochemical proof of this tissue compatibility.

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عنوان ژورنال:
gene, cell and tissue

جلد ۱، شماره ۲، صفحات ۰-۰

کلمات کلیدی
[ ' s m a l l c e l l l u n g c a r c i n o m a ' , ' a n t i g e n s ' , ' c d 5 6 ' , ' c h r o m o g r a n i n s ' , ' m o n o c l o n a l a n t i b o d y d 2 ' , 4 0 , ' p a r a n e o p l a s t i c s y n d r o m e ' ]

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