absence of immune response as a sign of tissue tolerance in small-cell lung cancer
نویسندگان
چکیده
background the attention of the scientific community has been recently focused on the role of tumor-infiltrating lymphocytes in non-small-cell cancer and there is a convergence of results, supporting a direct proportionality between lymphocytic infiltrate and good prognosis. objectives the aim of our research was to investigate the immune response around and inside the small-cell lung neoplastic tissue and its related neo-lymphangiogenesis in a group of 20 patients. materials and methods we have examined 20 bioptic samples of small cell lung cancer, obtained from 18 men and two women, aged 56-74 years old. besides hematoxylin-eosin staining, immunohistochemistry for neuroendocrine markers (cd56, chromogranin) and d2-40 was performed following the standard protocols. results our histological analysis, in all cases, has emerged the absence of an immune response supported by an adequate neo-lymphangiogenesis inside the neoplasia. conclusions the absence of an immune response is interpreted as a sign of tissue tolerance and host acceptance towards the cancer, in favor of the cancer metastatic spread. the development of a paraneoplastic syndrome can be considered a biochemical proof of this tissue compatibility.
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عنوان ژورنال:
gene, cell and tissueجلد ۱، شماره ۲، صفحات ۰-۰
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