association of the promoter methylation of mitochondrial transcription factor a with susceptibility to metabolic syndrome

نویسندگان

mohammad hashemi cellular and molecular research center, zahedan university of medical sciences, zahedan, ir iran; department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, ir iran; department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, ir iran. tel: +98-5413235122

hamzeh rezaei department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, ir iran

mahmoud ali kaykhaei department of internal medicine, school of medicine, zahedan university of medical sciences, zahedan, ir iran

mohsen taheri genetics of non-communicable disease research center, zahedan university of medical sciences, zahedan, ir iran

چکیده

conclusions no association was found between tfam promoter methylation and mes. the present study suggests that the tfam promoter methylation is not associated with risk of mes. objectives the aim of study was to investigate the possible association between promoter methylation of mitochondrial transcription factor a (tfam) and mes. patients and methods dna was extracted from peripheral blood of 151 patients with and 149 without mes. results tfam promoter methylation was evaluated by a nested methylation-specific pcr (nested msp). background it has been proposed that the patients with mitochondrial diseases usually manifest systemic metabolic disorders. the metabolic syndrome (mes), a cluster of several metabolic disorders, is increasingly being recognized as a risk factor for type 2 diabetes (t2d) and cardiovascular disease.

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عنوان ژورنال:
gene, cell and tissue

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