frequencies of two cyp2c19 defective alleles (cyp2c19*2, and *3) among iranian population in mazandaran province
نویسندگان
چکیده
background: cytochrome p450 2c19 (cyp2c19) is a polymorphically expressed enzyme that shows marked interindividual and interethnic variation. cyp2c19*2 and cyp2c19*3 are the most frequently identified defective alleles in orientals and caucasian poor metabolizers (pm). the aim of this study was to investigate the frequencies of cyp2c19*1, cyp2c19*2 and cyp2c19*3 alleles and cyp2c19 genotypes in the mazandarani ethnic group among iranian population. materials and methods: the study was conducted in 103 unrelated healthy volunteers. dna was extracted from leucocytes and analyzed by the pcr-rflp protocol. the pcr product was digested with restriction enzymes (smai and bamh1) and then separated electrophoretically using polyacrylamide gel.. results: of the alleles tested, cyp2c19*1, and cyp2c19*2, but not cyp2c19*3, were detected. the frequencies for cyp2c19 alleles *1, *2, and *3 were 91%, 9.0%, and 0.0%, respectively. the frequencies of cyp2c19 genotypes *1/*1, *1/*2, *1/*3, *2/*2, *2/*3 and *3/*3 were 84%, 14%, 0.0%, 2.0%, and 0.0%, respectively. conclusion: the result of the present study showed that the two inactive alleles of cyp2c19 accounted for 9.0% of cyp2c19 alleles in our sample versus 8.8 - 40.1% reported in other populations. the frequencies of the studied alleles resulted significant differences between our sample and african and eastern asian populations.
منابع مشابه
Frequencies of two CYP2C19 defective alleles (CYP2C19*2, and *3) among Iranian population in Mazandaran Province
Background: Cytochrome P450 2C19 (CYP2C19) is a polymorphically expressed enzyme that shows marked interindividual and interethnic variation. CYP2C19*2 and CYP2C19*3 are the most frequently identified defective alleles in Orientals and Caucasian poor metabolizers (PM). The aim of this study was to investigate the frequencies of CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles and CYP2C19 genotypes in...
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research in molecular medicineجلد ۱، شماره ۱، صفحات ۱۷-۲۱
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