the effect of natural adjuvants on pathological changes in sensitized guinea pig lungs

conclusions: these results indicate preventive effects of all natural adjuvants (especially g2) on pathological changes of the lung in sensitized guinea pigs. results: all pathological changes in s group including the eosinophil infiltration (scoring 3.28 ± 0.28), lymphocyte infiltration (2.82 ± 0.26), local epithelial necrosis (2.71 ± 0.47) and mucosal plug (2.75 ± 0.37) were significantly higher than control group (0.64 ± 0.18, 1.36 ± 0.24, 0.36 ± 0.18 and 0.28 ± 0.18 for eosinophil infiltration, lymphocyte infiltration, epithelial necrosis and mucosal plug respectively, p < 0.001 for all cases). treatment with all adjuvants improved all pathological changes significantly (p < 0.05 to p < 0.001). objectives: the effects of three natural adjuvants (pc, g2, and g2f registered as a patent in the iranian patent office) on sensitized guinea pigs lungs were examined in the present study. materials and methods: lung pathological changes were examined in control and five groups of randomly divided guinea pigs including: sensitized animals (s, receiving normal saline, 0.5 ml i.p.); sensitized animals treated with adjuvant pc; g2f (0.1 ml i.p. for both cases); g2 (0.4 ml i.p.); and pc + g2 (receiving both pc and g) adjuvants (twice a week for 4 weeks for all groups). sensitization of animals was done by injection and inhalation of ovalbumin (oa). background: anti-inflammatory effect of natural adjuvants has been reported. lung inflammation is the most characterized pathological feature in asthma.