evaluation of serum levels of n-terminal pro brain natriuretic peptide and atrial natriuretic peptide in neonates with respiratory distress
نویسندگان
چکیده
background: acute respiratory distress (ard) is a critical respiratory failure due to lung injury of neonates leading to the clinical appearance of poor lung compliance. the aimed of the study was to evaluate the diagnostic values in differentiating respiratory from heart diseases with using of n-terminal pro brain natriuretic peptide (nt-pro bnp) and atrial natriuretic peptide(anp) in neonates. material and methods: ninety neonates randomly collected from those who hospitalized in the neonate ward of the ali ebne abitalib hospital, zahedan, iran .after taking blood samples anp and nt pro brian natriuretic peptide using elisa kit were measured. the separated serum was kept in -20 °c until bnp measurement. 250 μl of the patients’ serum was isolated to assess pro bnp level using elisa kit (usa). data were analyzed using spss- 20 with considering of p< 0.05. results: nt pro-bnp level had the highest in cardiac patients and followed by respiratory. the level of nt pro-bnp for control neonates had the lowest. these levels had significant variation (p<0.05). the level of anp had the lowest for the cardiac patients. anp level had the lowest for the acyanotic. nt pro-bnp had the highest concentration in acyanotic patients and and had the second highest concentration in cyanotic. respiratory diseases ranked in the third levels in concentration of pro-bnp. the level of nt pro-bnp had the lowest for controls. the analysis showed a significant difference in the level of nt pro-bnp (p<0.05). conclusion: many studies revealed that nt pro-bnp cannot be used as a tool for differentiation between cardiac and respiratory as a cause of respiratory distress during neonate, but the results of the present study showed that it would be good biomarker.
منابع مشابه
Evaluation of Serum Levels of N-terminal Pro Brain Natriuretic Peptide and Atrial Natriuretic Peptide in Neonates with Respiratory Distress
Background: Acute respiratory distress (ARD) is a critical respiratory failure due to lung injury of neonates leading to the clinical appearance of poor lung compliance. The aimed of the study was to evaluate the diagnostic values in differentiating respiratory from heart diseases with using of N-terminal pro brain natriuretic peptide (NT-pro BNP) and Atrial natriuretic peptide(ANP) in neonates...
متن کاملEvaluation of Serum NT-Pro Brain Natriuretic Peptide Levels in Neonates with Respiratory Distress
Background Respiratory Distress (RD) is a life-threatening respiratory failure. This study aimed to evaluate the diagnostic value of N-terminal prohormone of brain natriuretic peptide (NT-pro-BNP) in distinguishing respiratory and heart diseases in neonates. Materials and Methods Hundred fifty neonates aged 2-3 days randomly collected from those who hospitalized in the related ward of the Ali ...
متن کاملN-terminal Pro-Brain Natriuretic Peptide And Atrial Fibrillation
NT-proBNP is produced from both atria and ventricles. The primary regulation of production is at the synthesis level. The plasma half-life of NT-proBNP is 60-120 min. Cutoff value of NT-proBNP for diagnosis of heart failure is 125 pg/ml in the age group below 75 years and 450 pg/ml in the age group above 75 years. It increases in atrial fibrillation and drops after successful cardioversion. Hig...
متن کاملبررسی ارتباط سطح سرمی N-terminal Pro-brain Natriuretic Peptide و شدت پره‌اکلامپسی
Background and purpose: Preeclampsia is a serious condition in pregnancy. Previous studies have shown that NT-pro BNP level is higher in preeclamptic patients than that in pregnant women with normal blood pressure. Severity of preeclampsia is one of the critical factors in managing patients, so, this study aimed at investigating the relationship between the level of NT-pro BNP and severity of ...
متن کاملuse of brain natriuretic peptide in predicting severity of respiratory distress syndrome in neonates
متن کامل
Risk assessment in patients with unstable angina/non-ST-elevation myocardial infarction and normal N-terminal pro-brain natriuretic peptide levels by N-terminal pro-atrial natriuretic peptide.
AIMS To compare the accuracy of the N-terminal fragment of its pro-hormone (Nt-proBNP) and N-terminal pro-atrial natriuretic peptide (Nt-proANP) in the prediction of the 2 year mortality and to investigate whether additional measurement of Nt-proANP to troponin I (TnI) could improve risk assessment in the subgroups of patients with unstable coronary artery disease (UCAD) and normal Nt-proBNP. ...
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عنوان ژورنال:
international journal of pediatricsجلد ۴، شماره ۶، صفحات ۱۸۴۷-۱۸۵۶
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