chromosome structural alteration an unusual abnormality characterizing human neoplasia
نویسندگان
چکیده
background and aim: ring chromosomes are rare cytogenetic abnormalities that occur in less than 10% of hematopoietic malignancies. they are rare in blood disorder. the present review has focused on the ring chromosome associated with oncology malignancies. materials and methods: by reviewing the web-based search for all english scientific peer review articles published, was initiated using medline/pubmed, mitelman database ( http://cgap.nci.nih.gov/chromosomes/mitelman ), and other pertinent references on websites about ring chromosomes in oncology. the software program as end note was used to handle the proper references for instruction to author. karyotype descriptions were cited according to iscn. conclusion: ring chromosomes are rare chromosomal aberrations, almost many times are of de novo origin, presenting a different phenotype regarding the loss of genetic material. the karyotype represents the main analysis for detection of ring chromosomes, but other molecular technics are necessary for complete characterization. the information of this review article adds to the spectrum of both morphology and genetic rearrangements in the field of oncology malignancies.
منابع مشابه
Rare chromosome structural aberration characterizing oncology malignancy.
UNLABELLED Ring chromosome aberration are rare abnormality potentially involving any chromosome in patients diagnosing in Oncology. The present review and case study has focused on the ring chromosome associated with oncology malignancies. MATERIAL AND METHODS An electronic peer review article search was performed systematically to obtain relevant literature with the CINAHL, Google scholar, a...
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متن کاملSELF ASSESSMENT ANSWERS An unusual electrocardiographic abnormality
Q1: What is shown in fig 1 (see p 539), and what is its significance? Figure 1 shows a prolonged QT interval (corrected QT 520 milliseconds) and macroscopic T wave alternans. T wave alternans is defined as a beat to beat variation in the amplitude or polarity of the T wave. Macroscopic T wave alternans is a predictor of malignant ventricular arrhythmias. Microvolt T wave alternans is a validate...
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عنوان ژورنال:
novelty in biomedicineجلد ۴، شماره ۲، صفحات ۷۷-۸۳
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