clinical utility of indigenously formulated single-vial lyophilized hynic-toc kit in evaluating gastro-entero pancreatic neuro endocrine tumours
نویسندگان
چکیده
objective(s): the objective of this study was to evaluate the performance and utility of 99mtc hynic-toc planar scintigraphy and spect/ct in the diagnosis, staging and management of gastroenteropancreatic neuroendocrine tumors (gpnets). methods: 22 patients (median age, 46 years) with histologically proven gastroentero-pancreatic nets underwent 99mtc hynic-toc whole body scintigraphy and regional spect/ct as indicated. scanning was performed after injection of 370-550 mbq (10-15 mci) of 99mtc hynic-toc intravenously. images were evaluated by two experienced nuclear medicine physicians both qualitatively as well as semi quantitatively (tumor to background and tumor to normal liver ratios on spect -ct images). results of spect/ct were compared with the results of conventional imaging. histopathology results and follow-up somatostatin receptor scintigraphy with 99mtc hynic toc or conventional imaging with biochemical markers were considered to be the reference standards. results: 99mtc hynic toc showed sensitivity and specificity of 87.5% and 85.7%, respectively, for primary tumor and 100% and 86% for metastases. it was better than conventional imaging modalities for the detection of both primary tumor (p<0.001) and metastases (p<0.0001). it changed the management strategy in 6 patients (31.8%) and supported management decisions in 8 patients (36.3%). conclusion: 99mtc hynic toc spect/ct appears to be a highly sensitive and specific modality for the detection and staging of gpnets. it is better than conventional imaging for the evaluation of gpnets and can have a significant impact on patient management and planning further therapeutic options.
منابع مشابه
Clinical utility of indigenously formulated single-vial lyophilized HYNIC-TOC kit in evaluating Gastro-entero Pancreatic neuro endocrine tumours
Objective(s): The objective of this study was to evaluate the performance and utility of 99mTc HYNIC-TOC planar scintigraphy and SPECT/CT in the diagnosis, staging and management of gastroenteropancreatic neuroendocrine tumors (GPNETs). Methods: 22 patients (median age, 46 years) with histologically proven gastroentero-pancreatic NETs underwent 99mTc HYNIC-TOC whole body scintigraphy and regi...
متن کاملClinical utility of indigenously formulated single-vial lyophilized HYNIC-TOC kit in evaluating Gastro-entero Pancreatic neuro endocrine tumours
OBJECTIVES The objective of this study was to evaluate the performance and utility of (99m)Tc HYNIC-TOC planar scintigraphy and SPECT/CT in the diagnosis, staging and management of gastroenteropancreatic neuroendocrine tumors (GPNETs). METHODS 22 patients (median age, 46 years) with histologically proven gastro- entero- pancreatic NETs underwent (99m)Tc HYNIC-TOC whole body scintigraphy and r...
متن کاملScreening for malnutrition in patients with gastro-entero-pancreatic neuroendocrine tumours: a cross-sectional study
OBJECTIVES To investigate whether screening for malnutrition using the validated malnutrition universal screening tool (MUST) identifies specific characteristics of patients at risk, in patients with gastro-entero-pancreatic neuroendocrine tumours (GEP-NET). DESIGN Cross-sectional study. SETTING University Hospitals Coventry & Warwickshire NHS Trust; European Neuroendocrine Tumour Society C...
متن کاملNeuroendocrine tumors of the gastro-entero-pancreatic system.
Gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs) are rare neoplasms, although their prevalence has increased substantially over the past three decades. Moreover, there has been an increased clinical recognition and characterization of these neoplasms. They show extremely variable biological behavior and clinical course. Most NETs have endocrine function and secrete peptides and neuro...
متن کاملThe effect of alcohol on gastro-entero-pancreatic hormones.
OWING to the association between alcohol and chronic pancreatitis in man' there has,been considerable interest in the effect of alcohol upon gastro-entero pancreatic (GEP) hormones. Previous estimations of GEP hormones following oral alcohol ingestion have shown raised serum gastrin concentrations in response to 18 per cent and 15 per cent ethanol in man (Becker, Reeder and Thompson2), and Stra...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
asia oceania journal of nuclear medicine and biologyجلد ۲، شماره ۱، صفحات ۳۰-۴۱
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023